[18F] FDOPA standardized uptake values of brain tumors are not exclusively dependent on LAT1 expression.

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  • Additional Information
    • Publication Year:
      2017
    • Author-Supplied Keywords:
      Basic cancer research
      Biology and life sciences
      Blastomas
      Cancer chemotherapy
      Cancer treatment
      Cancers and neoplasms
      Chemotherapy
      Clinical medicine
      Clinical oncology
      Diagnostic medicine
      Diagnostic radiology
      Drug therapy
      Glioblastoma multiforme
      Glioma
      Imaging techniques
      Immune response
      Immunology
      Inflammation
      Medicine and health sciences
      Metastasis
      Neuroimaging
      Neurological tumors
      Neurology
      Neuroscience
      Oncology
      Pathology and laboratory medicine
      Pharmaceutics
      Positron emission tomography
      Radiation therapy
      Radiology and imaging
      Research and analysis methods
      Research Article
      Signs and symptoms
      Tomography
    • NAICS/Industry Codes:
      NAICS/Industry Codes 621512 Diagnostic Imaging Centers
    • Abstract:
      [18F]-FDOPA is a labeled amino acid (AA) analog used for positron emission tomography (PET) which is gaining increasing interest in the evaluation of brain tumors (BT). The AA-transporter LAT1 has been shown to be involved in [18F]-FDOPA uptake. The aim of this study was to determine whether the [18F]-FDOPA uptake was correlated with level of LAT1 expression in BT. Twenty-eight BT (including 19 gliomas and 9 metastases) were investigated by [18F]-FDOPA-PET prior to surgery and by anti-LAT1 immunohistochemistry on surgical specimens. The quantitative [18F]-FDOPA measured parameters were SUVmax, SUVmean and SUVpeak. LAT1 expression was quantified using a score (0 to 400). A significant [18F]-FDOPA uptake was associated with a LAT1 score ≥ 100 (p = 0.02) but there was no linear correlation between intensity of [18F]-FDOPA uptake and score of LAT1 expression whatever the parameters considered. LAT1 expression alone is not sufficient to explain variation of intensity of [18F]-FDOPA uptake in BT. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • ISSN:
      19326203
    • Accession Number:
      125303289
  • Citations
    • ABNT:
      DADONE-MONTAUDIÉ, B. et al. [18F] FDOPA standardized uptake values of brain tumors are not exclusively dependent on LAT1 expression. PLoS ONE, [s. l.], v. 12, n. 9, p. 1, 2017. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=125303289. Acesso em: 26 jan. 2020.
    • AMA:
      Dadone-Montaudié B, Ambrosetti D, Dufour M, et al. [18F] FDOPA standardized uptake values of brain tumors are not exclusively dependent on LAT1 expression. PLoS ONE. 2017;12(9):1. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=125303289. Accessed January 26, 2020.
    • APA:
      Dadone-Montaudié, B., Ambrosetti, D., Dufour, M., Darcourt, J., Almairac, F., Coyne, J., … Burel-Vandenbos, F. (2017). [18F] FDOPA standardized uptake values of brain tumors are not exclusively dependent on LAT1 expression. PLoS ONE, 12(9), 1. Retrieved from http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=125303289
    • Chicago/Turabian: Author-Date:
      Dadone-Montaudié, Bérengère, Damien Ambrosetti, Maxime Dufour, Jacques Darcourt, Fabien Almairac, John Coyne, Thierry Virolle, Olivier Humbert, and Fanny Burel-Vandenbos. 2017. “[18F] FDOPA Standardized Uptake Values of Brain Tumors Are Not Exclusively Dependent on LAT1 Expression.” PLoS ONE 12 (9): 1. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=125303289.
    • Harvard:
      Dadone-Montaudié, B. et al. (2017) ‘[18F] FDOPA standardized uptake values of brain tumors are not exclusively dependent on LAT1 expression’, PLoS ONE, 12(9), p. 1. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=125303289 (Accessed: 26 January 2020).
    • Harvard: Australian:
      Dadone-Montaudié, B, Ambrosetti, D, Dufour, M, Darcourt, J, Almairac, F, Coyne, J, Virolle, T, Humbert, O & Burel-Vandenbos, F 2017, ‘[18F] FDOPA standardized uptake values of brain tumors are not exclusively dependent on LAT1 expression’, PLoS ONE, vol. 12, no. 9, p. 1, viewed 26 January 2020, .
    • MLA:
      Dadone-Montaudié, Bérengère, et al. “[18F] FDOPA Standardized Uptake Values of Brain Tumors Are Not Exclusively Dependent on LAT1 Expression.” PLoS ONE, vol. 12, no. 9, Sept. 2017, p. 1. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=125303289.
    • Chicago/Turabian: Humanities:
      Dadone-Montaudié, Bérengère, Damien Ambrosetti, Maxime Dufour, Jacques Darcourt, Fabien Almairac, John Coyne, Thierry Virolle, Olivier Humbert, and Fanny Burel-Vandenbos. “[18F] FDOPA Standardized Uptake Values of Brain Tumors Are Not Exclusively Dependent on LAT1 Expression.” PLoS ONE 12, no. 9 (September 22, 2017): 1. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=125303289.
    • Vancouver/ICMJE:
      Dadone-Montaudié B, Ambrosetti D, Dufour M, Darcourt J, Almairac F, Coyne J, et al. [18F] FDOPA standardized uptake values of brain tumors are not exclusively dependent on LAT1 expression. PLoS ONE [Internet]. 2017 Sep 22 [cited 2020 Jan 26];12(9):1. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=125303289