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Controlled oxygenated rewarming up to normothermia for pretransplant reconditioning of liver grafts.
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- Author(s): Horn, Charlotte; Baba, Hideo A.; Hannaert, Patrik; Hauet, Thierry; Leuvenink, Henri; Paul, Andreas; Minor, Thomas
- Source:
Clinical Transplantation; Nov2017, Vol. 31 Issue 11, pn/a-N.PAG, 7p- Subject Terms:
- Source:
- Additional Information
- Abstract: Controlled oxygenated rewarming ( COR) up to 20°C during ex vivo machine perfusion limits reperfusion-induced tissue injury upon graft implantation. Rewarming up to normothermia might add further benefits and provide better prediction of post-transplantation organ function. The effect of 90 minutes of oxygenated machine perfusion with Aqix RS-I after cold storage combined with gentle rewarming up to 20°C ( COR20) or 35°C ( COR35) was studied in rat livers and compared with cold storage alone ( CS, n = 6, resp). Postpreservation recovery was evaluated upon warm reperfusion using an established in vitro system. COR generally resulted in significantly improved energetic recovery, increased bile flow, less activities alanine aminotransferase ( ALT) release, and improved histopathology upon reperfusion as compared to only cold-stored livers, without significant differences between COR20 and COR35. Parameters obtained during COR, especially during COR35, also allowed for prediction of hepatic recovery upon reperfusion. For instance, ulterior bile production upon reperfusion was found closely correlated to bile flow observed already during COR35 (R2 = 0.91). COR significantly improved liver quality after static cold storage. Elevation of machine perfusion temperature up to 35°C may prove promising to refine ex vivo evaluation of the graft prior to transplantation. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Clinical Transplantation is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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