Effect of Zinc Supplementation on Maintenance Hemodialysis Patients: A Systematic Review and Meta-Analysis of 15 Randomized Controlled Trials.

Item request has been placed! ×
Item request cannot be made. ×
  Processing Request
  • Additional Information
    • Publication Year:
      2017
    • NAICS/Industry Codes:
      NAICS/Industry Codes 414510 Pharmaceuticals and pharmacy supplies merchant wholesalers
      446191 Food (Health) Supplement Stores
      416210 Metal service centres
    • Abstract:
      We aimed to examine the effects of zinc supplementation on nutritional status, lipid profile, and antioxidant and anti-inflammatory therapies in maintenance hemodialysis (MHD) patients. We performed a systematic review and meta-analysis of randomized, controlled clinical trials of zinc supplementation. Metaregression analyses were utilized to determine the cause of discrepancy. Begg and Egger tests were performed to assess publication bias. Subgroup analysis was utilized to investigate the effects of zinc supplementation in certain conditions. In the crude pooled results, we found that zinc supplementation resulted in higher serum zinc levels (weighted mean difference [WMD] = 28.489; P<0.001), higher dietary protein intake (WMD = 8.012; P<0.001), higher superoxide dismutase levels (WMD = 357.568; P=0.001), and lower levels of C-reactive protein (WMD = −8.618; P=0.015) and malondialdehyde (WMD = −1.275; P<0.001). The results showed no differences in lipid profile. In the metaregression analysis, we found that serum zinc levels correlated positively with intervention time (β=0.272; P=0.042) and varied greatly by ethnicity (P=0.023). Results from Begg and Egger tests showed that there was no significant bias in our meta-analysis (P>0.1). Results of subgroup analysis supported the above results. Our analysis shows that zinc supplementation may benefit the nutritional status of MHD patients and show a time-effect relationship. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of BioMed Research International is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • ISSN:
      23146133
    • Accession Number:
      127053396
  • Citations
    • ABNT:
      WANG, L.-J. et al. Effect of Zinc Supplementation on Maintenance Hemodialysis Patients: A Systematic Review and Meta-Analysis of 15 Randomized Controlled Trials. BioMed Research International, [s. l.], v. 2017, p. 1, 2017. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=127053396. Acesso em: 13 dez. 2019.
    • AMA:
      Wang L-J, Wang M-Q, Hu R, et al. Effect of Zinc Supplementation on Maintenance Hemodialysis Patients: A Systematic Review and Meta-Analysis of 15 Randomized Controlled Trials. BioMed Research International. 2017;2017:1. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=127053396. Accessed December 13, 2019.
    • APA:
      Wang, L.-J., Wang, M.-Q., Hu, R., Yang, Y., Huang, Y.-S., Xian, S.-X., & Lu, L. (2017). Effect of Zinc Supplementation on Maintenance Hemodialysis Patients: A Systematic Review and Meta-Analysis of 15 Randomized Controlled Trials. BioMed Research International, 2017, 1. Retrieved from http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=127053396
    • Chicago/Turabian: Author-Date:
      Wang, Ling-Jun, Ming-Qing Wang, Rong Hu, Yi Yang, Yu-Sheng Huang, Shao-Xiang Xian, and Lu Lu. 2017. “Effect of Zinc Supplementation on Maintenance Hemodialysis Patients: A Systematic Review and Meta-Analysis of 15 Randomized Controlled Trials.” BioMed Research International 2017 (December): 1. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=127053396.
    • Harvard:
      Wang, L.-J. et al. (2017) ‘Effect of Zinc Supplementation on Maintenance Hemodialysis Patients: A Systematic Review and Meta-Analysis of 15 Randomized Controlled Trials’, BioMed Research International, 2017, p. 1. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=127053396 (Accessed: 13 December 2019).
    • Harvard: Australian:
      Wang, L-J, Wang, M-Q, Hu, R, Yang, Y, Huang, Y-S, Xian, S-X & Lu, L 2017, ‘Effect of Zinc Supplementation on Maintenance Hemodialysis Patients: A Systematic Review and Meta-Analysis of 15 Randomized Controlled Trials’, BioMed Research International, vol. 2017, p. 1, viewed 13 December 2019, .
    • MLA:
      Wang, Ling-Jun, et al. “Effect of Zinc Supplementation on Maintenance Hemodialysis Patients: A Systematic Review and Meta-Analysis of 15 Randomized Controlled Trials.” BioMed Research International, vol. 2017, Dec. 2017, p. 1. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=127053396.
    • Chicago/Turabian: Humanities:
      Wang, Ling-Jun, Ming-Qing Wang, Rong Hu, Yi Yang, Yu-Sheng Huang, Shao-Xiang Xian, and Lu Lu. “Effect of Zinc Supplementation on Maintenance Hemodialysis Patients: A Systematic Review and Meta-Analysis of 15 Randomized Controlled Trials.” BioMed Research International 2017 (December 31, 2017): 1. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=127053396.
    • Vancouver/ICMJE:
      Wang L-J, Wang M-Q, Hu R, Yang Y, Huang Y-S, Xian S-X, et al. Effect of Zinc Supplementation on Maintenance Hemodialysis Patients: A Systematic Review and Meta-Analysis of 15 Randomized Controlled Trials. BioMed Research International [Internet]. 2017 Dec 31 [cited 2019 Dec 13];2017:1. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=127053396