Joint approach of diffusion- and perfusion-weighted MRI in intra-axial mass like lesions in clinical practice simulation.

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  • Additional Information
    • Publication Year:
      2018
    • Author-Supplied Keywords:
      Abscesses
      Biology and life sciences
      Brain mapping
      Brain morphometry
      Cancer detection and diagnosis
      Cancers and neoplasms
      Diagnostic medicine
      Diagnostic radiology
      Diffusion weighted imaging
      Hematologic cancers and related disorders
      Hematology
      Imaging techniques
      Lesions
      Lymphomas
      Magnetic resonance imaging
      Medicine and health sciences
      Neoplasms
      Neuroimaging
      Neuroscience
      Oncology
      Pathology and laboratory medicine
      Radiology and imaging
      Research and analysis methods
      Research Article
      Signs and symptoms
    • NAICS/Industry Codes:
      NAICS/Industry Codes 621512 Diagnostic Imaging Centers
    • Abstract:
      Although advanced magnetic resonance imaging (MRI) techniques provide useful information for the differential diagnosis of intra-axial mass-like lesions, the specific diagnostic role of multimodal MRI over conventional magnetic resonance imaging (CMRI) alone in the differential diagnosis of mass-like lesions from a large heterogeneous cohort has not been studied. In this study, we aimed to determine the added value of a joint approach of diffusion-weighted imaging (DWI) and dynamic-susceptibility-contrast perfusion imaging (DSC-PWI) for diagnosis of intra-axial mass-like lesions, comparing them with CMRI alone. Furthermore, we performed these evaluations in a manner simulating clinical practice. Our institutional review board approved this retrospective study and waived the requirement for informed consent. A total of 1038 patients with intra-axial mass-like lesions were retrospectively recruited according to their histological and clinico-radiological diagnoses made between January 2005 and December 2014. All patients underwent CMRI, DWI and DSC-PWI. The diagnostic accuracy and confidence in diagnosing each type of intra-axial mass-like lesions, and for differentiating the intra-axial brain tumors from non-neoplastic lesions, were compared according to the MRI protocols. The disease-specific sensitivity of joint approach differed according to specific disease entities in diagnosing each disease category. Joint approach provided the best diagnostic accuracy for discriminating intra-axial brain tumors from non-neoplastic lesions, with high diagnostic accuracy (95.3–96.7%), specificity (82–84.0%), positive-predictive-value (97.0–97.3%), and negative-predictive-value (84.8–92.7%), with the reader’s confidence values being significantly improved over those on CMRI alone (all p-values < 0.001). In conclusion, joint approach of DWI, DSC-PWI to CMRI helps to differentiate non-neoplastic lesions from intra-axial brain tumors, and improves diagnostic confidence compared with CMRI alone. The benefit from the combined imaging differs for each disease category; thus joint approach needs to be customized according to clinical suspicion. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • ISSN:
      19326203
    • Accession Number:
      131668141
  • Citations
    • ABNT:
      YOON, R. G. et al. Joint approach of diffusion- and perfusion-weighted MRI in intra-axial mass like lesions in clinical practice simulation. PLoS ONE, [s. l.], v. 13, n. 9, p. 1, 2018. Disponível em: . Acesso em: 24 ago. 2019.
    • AMA:
      Yoon RG, Kim HS, Hong GS, et al. Joint approach of diffusion- and perfusion-weighted MRI in intra-axial mass like lesions in clinical practice simulation. PLoS ONE. 2018;13(9):1. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=131668141. Accessed August 24, 2019.
    • APA:
      Yoon, R. G., Kim, H. S., Hong, G. S., Park, J. E., Jung, S. C., Kim, S. J., & Kim, J. H. (2018). Joint approach of diffusion- and perfusion-weighted MRI in intra-axial mass like lesions in clinical practice simulation. PLoS ONE, 13(9), 1. Retrieved from http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=131668141
    • Chicago/Turabian: Author-Date:
      Yoon, Ra Gyoung, Ho Sung Kim, Gil Sun Hong, Ji Eun Park, Seung Chai Jung, Sang Joon Kim, and Jeong Hoon Kim. 2018. “Joint Approach of Diffusion- and Perfusion-Weighted MRI in Intra-Axial Mass like Lesions in Clinical Practice Simulation.” PLoS ONE 13 (9): 1. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=131668141.
    • Harvard:
      Yoon, R. G. et al. (2018) ‘Joint approach of diffusion- and perfusion-weighted MRI in intra-axial mass like lesions in clinical practice simulation’, PLoS ONE, 13(9), p. 1. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=131668141 (Accessed: 24 August 2019).
    • Harvard: Australian:
      Yoon, RG, Kim, HS, Hong, GS, Park, JE, Jung, SC, Kim, SJ & Kim, JH 2018, ‘Joint approach of diffusion- and perfusion-weighted MRI in intra-axial mass like lesions in clinical practice simulation’, PLoS ONE, vol. 13, no. 9, p. 1, viewed 24 August 2019, .
    • MLA:
      Yoon, Ra Gyoung, et al. “Joint Approach of Diffusion- and Perfusion-Weighted MRI in Intra-Axial Mass like Lesions in Clinical Practice Simulation.” PLoS ONE, vol. 13, no. 9, Sept. 2018, p. 1. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=131668141.
    • Chicago/Turabian: Humanities:
      Yoon, Ra Gyoung, Ho Sung Kim, Gil Sun Hong, Ji Eun Park, Seung Chai Jung, Sang Joon Kim, and Jeong Hoon Kim. “Joint Approach of Diffusion- and Perfusion-Weighted MRI in Intra-Axial Mass like Lesions in Clinical Practice Simulation.” PLoS ONE 13, no. 9 (September 7, 2018): 1. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=131668141.
    • Vancouver/ICMJE:
      Yoon RG, Kim HS, Hong GS, Park JE, Jung SC, Kim SJ, et al. Joint approach of diffusion- and perfusion-weighted MRI in intra-axial mass like lesions in clinical practice simulation. PLoS ONE [Internet]. 2018 Sep 7 [cited 2019 Aug 24];13(9):1. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=131668141