Evaluation of vascular endothelial growth factor levels in tears and serum among diabetic patients.

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  • Additional Information
    • Publication Year:
      2019
    • Author-Supplied Keywords:
      Anatomy
      Biology and life sciences
      Blood pressure
      Diabetes mellitus
      Diabetic retinopathy
      Endocrine disorders
      Endocrine physiology
      Endocrinology
      Eyes
      Growth factors
      Head
      Hypertension
      Linear regression analysis
      Mathematical and statistical techniques
      Mathematics
      Medicine and health sciences
      Metabolic disorders
      Ocular anatomy
      Ocular system
      Ophthalmology
      Physical sciences
      Physiology
      Regression analysis
      Research and analysis methods
      Research Article
      Retina
      Retinal disorders
      Retinopathy
      Statistical methods
      Statistics
      Type 2 diabetes
      Vascular medicine
    • NAICS/Industry Codes:
      NAICS/Industry Codes 418220 Other paper and disposable plastic product merchant wholesalers
      322299 All Other Converted Paper Product Manufacturing
      424130 Industrial and Personal Service Paper Merchant Wholesalers
    • Abstract:
      Objective: Detection of vascular endothelial growth factor (VEGF) levels in ocular tissue may perhaps provide insight into the role of VEGF in the pathogenesis and progression of diabetic retinopathy (DR). The aim of this study was to evaluate the levels of VEGF in tears and serum amongst type 2 diabetes mellitus (DM) patients. Methods: A comparative cross-sectional study was conducted between August 2016 and May 2018 involving type 2 DM patients with no DR, non-proliferative DR (NPDR), and proliferative DR (PDR). Tear samples were collected using no.41 Whatman filter paper (Schirmer strips) and 5 mL blood samples were drawn by venous puncture. VEGF levels in tears and serum were measured by enzyme-linked immunosorbent assay. Results: A total of 88 type 2 DM patients (no DR: 30 patients, NPDR: 28 patients, PDR: 30 patients) were included in the study. Mean tear VEGF levels were significantly higher in the NPDR and PDR groups (114.4 SD 52.5 pg/mL and 150.8 SD 49.7 pg/mL, respectively) compared to the no DR group (40.4 SD 26.5 pg/mL, p < 0.001). There was no significant difference in the mean serum VEGF levels between the three groups. There was a fair correlation between serum and tear VEGF levels (p = 0.015, r = 0.263). Conclusion: VEGF levels in tears were significantly higher amongst diabetic patients with DR compared to those without DR and were significantly associated with the severity of DR. There was a fair correlation between serum and tear VEGF levels. Detection of VEGF in tears is a good non-invasive predictor test for the severity of DR. A large cohort study is needed for further evaluation. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • ISSN:
      19326203
    • Accession Number:
      138192061
  • Citations
    • ABNT:
      ANG, W. J. et al. Evaluation of vascular endothelial growth factor levels in tears and serum among diabetic patients. PLoS ONE, [s. l.], v. 14, n. 8, p. 1, 2019. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=138192061. Acesso em: 10 jul. 2020.
    • AMA:
      Ang WJ, Zunaina E, Norfadzillah AJ, et al. Evaluation of vascular endothelial growth factor levels in tears and serum among diabetic patients. PLoS ONE. 2019;14(8):1. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=138192061. Accessed July 10, 2020.
    • AMA11:
      Ang WJ, Zunaina E, Norfadzillah AJ, et al. Evaluation of vascular endothelial growth factor levels in tears and serum among diabetic patients. PLoS ONE. 2019;14(8):1. Accessed July 10, 2020. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=138192061
    • APA:
      Ang, W. J., Zunaina, E., Norfadzillah, A. J., Raja-Norliza, R. O., Julieana, M., Ab-Hamid, S. A., & Mahaneem, M. (2019). Evaluation of vascular endothelial growth factor levels in tears and serum among diabetic patients. PLoS ONE, 14(8), 1.
    • Chicago/Turabian: Author-Date:
      Ang, Wen Jeat, Embong Zunaina, Abdul Jalil Norfadzillah, Raja Omar Raja-Norliza, Muhammed Julieana, Siti Azrin Ab-Hamid, and Mohamed Mahaneem. 2019. “Evaluation of Vascular Endothelial Growth Factor Levels in Tears and Serum among Diabetic Patients.” PLoS ONE 14 (8): 1. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=138192061.
    • Harvard:
      Ang, W. J. et al. (2019) ‘Evaluation of vascular endothelial growth factor levels in tears and serum among diabetic patients’, PLoS ONE, 14(8), p. 1. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=138192061 (Accessed: 10 July 2020).
    • Harvard: Australian:
      Ang, WJ, Zunaina, E, Norfadzillah, AJ, Raja-Norliza, RO, Julieana, M, Ab-Hamid, SA & Mahaneem, M 2019, ‘Evaluation of vascular endothelial growth factor levels in tears and serum among diabetic patients’, PLoS ONE, vol. 14, no. 8, p. 1, viewed 10 July 2020, .
    • MLA:
      Ang, Wen Jeat, et al. “Evaluation of Vascular Endothelial Growth Factor Levels in Tears and Serum among Diabetic Patients.” PLoS ONE, vol. 14, no. 8, Aug. 2019, p. 1. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=138192061.
    • Chicago/Turabian: Humanities:
      Ang, Wen Jeat, Embong Zunaina, Abdul Jalil Norfadzillah, Raja Omar Raja-Norliza, Muhammed Julieana, Siti Azrin Ab-Hamid, and Mohamed Mahaneem. “Evaluation of Vascular Endothelial Growth Factor Levels in Tears and Serum among Diabetic Patients.” PLoS ONE 14, no. 8 (August 22, 2019): 1. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=138192061.
    • Vancouver/ICMJE:
      Ang WJ, Zunaina E, Norfadzillah AJ, Raja-Norliza RO, Julieana M, Ab-Hamid SA, et al. Evaluation of vascular endothelial growth factor levels in tears and serum among diabetic patients. PLoS ONE [Internet]. 2019 Aug 22 [cited 2020 Jul 10];14(8):1. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=138192061