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Childhood methylphenidate adherence as a predictor of antidepressants use during adolescence.
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- Author(s): Madjar, Nir; Shlosberg, Dan; Leventer-Roberts, Maya; Akriv, Amichay; Ghilai, Adi; Hoshen, Moshe; Krivoy, Amir; Zalsman, Gil; Shoval, Gal
- Source:
European Child & Adolescent Psychiatry; Oct2019, Vol. 28 Issue 10, p1365-1373, 9p, 1 Diagram, 3 Charts- Subject Terms:
ANTIDEPRESSANTS; METHYLPHENIDATE; RISK factors of attention-deficit hyperactivity disorder; AGE factors in disease; ATTENTION-deficit hyperactivity disorder; CHILDREN'S health; DRUGS; EMOTIONS; HEALTH insurance; INTEGRATED health care delivery; LONGITUDINAL method; MEDICAL prescriptions; PATIENT compliance; RISK assessment; ADOLESCENT health; COMORBIDITY; LOGISTIC regression analysis; EARLY intervention (Education); PARENT attitudes; THERAPEUTICS - Source:
- Additional Information
- Abstract: Methylphenidate (MPH) is a common and effective treatment for attention deficit hyperactivity disorder (ADHD), but little is known about the relationship between early childhood intake of MPH and onset of antidepressant treatment during adolescence. The study aimed to examine whether adherence to MPH during early childhood predicts the initiation of antidepressants during adolescence. This is a 12-year historical prospective nationwide cohort study of children enrolled in an integrated care system who were first prescribed MPH between the ages of 6 and 8 years (N = 6830). We tested for an association between their adherence to MPH during early childhood (as indicated by medication possession ratio from MPH onset through the age of twelve) and the likelihood of being prescribed any antidepressant during adolescence (age 13–18). As all country citizens are covered by mandatory health insurance, and full services are provided by one of the four integrated care systems, data regarding patients' diagnoses, prescriptions, and medical purchases are well documented. Logistic regression analysis indicated that those with higher adherence to MPH had a 50% higher risk (95% CI 1.16–1.93) of receiving antidepressants during adolescence when controlling for other comorbid psychiatric conditions and parental use of antidepressants. In this large-scale longitudinal study, MPH adherence during early childhood emerged as a predictor for antidepressant treatment during adolescence, which may reflect increased emotional and behavioral dysregulation in this group. The highly adherent patients are at higher risk and should be clinically monitored more closely, particularly into adolescence. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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