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9 a.m. – 7 p.m.
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Neuronal HMGB1 in nucleus accumbens regulates cocaine reward memory.
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- Author(s): Gao, Shuang‐Qi; Zhang, Hai; He, Jin‐Gang; Zheng, Hui‐Ling; Zhang, Pei‐Wei; Xu, Jun‐Feng; Shen, Zu‐Cheng; Zhao, Huan‐Huan; Wang, Fang; Hu, Zhuang‐Li; Chen, Jian‐Guo; Gao, Shuang-Qi; He, Jin-Gang; Zheng, Hui-Ling; Zhang, Pei-Wei; Xu, Jun-Feng; Shen, Zu-Cheng; Zhao, Huan-Huan; Hu, Zhuang-Li; Chen, Jian-Guo
- Source:
Addiction Biology; Mar2020, Vol. 25 Issue 2, pN.PAG-N.PAG, 1p- Subject Terms:
NUCLEUS accumbens; COCAINE abuse; CENTRAL nervous system; GLUTAMATE receptors; COCAINE; LONG-term synaptic depression; DRUG-seeking behavior; MEMORY; PROTEINS; BIOLOGICAL models; RESEARCH; SUBSTANCE abuse; NEURONS; BASAL ganglia; ANIMAL experimentation; RESEARCH methodology; EVALUATION research; MEDICAL cooperation; RATS; COMPARATIVE studies; REWARD (Psychology); RESEARCH funding; PHARMACODYNAMICS - Source:
- Additional Information
- Abstract: Cocaine is a common abused drug that can induce abnormal synaptic and immune responses in the central nervous system (CNS). High mobility group box 1 (HMGB1) is one kind of inflammatory molecules that is expressed both on neurons and immune cells. Previous studies of HMGB1 in the CNS have largely focused on immune function, and the role of HMGB1 in neurons and cocaine addiction remains unknown. Here, we show that cocaine exposure induced the translocation and release of HMGB1 in the nucleus accumbens (NAc) neurons. Gain and loss of HMGB1 in the NAc bidirectionally regulate cocaine-induced conditioned place preference. From the nucleus to the cytosol, HMGB1 binds to glutamate receptor subunits (GluA2/GluN2B) on the membrane, which regulates cocaine-induced synaptic adaptation and the formation of cocaine-related memory. These data unveil the role of HMGB1 in neurons and provide the evidence for the HMGB1 involvement in drug addiction. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Addiction Biology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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