Expression of insulin-like growth factors in remyelination following ethidium bromide-induced demyelination in the mouse spinal cord.

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  • Additional Information
    • Publication Year:
      2004
    • Author-Supplied Keywords:
      insulin-like growth factor-I
      insulin-like growth factor-I receptor
      insulin-like growth factor-II receptor
      insulin-like growth factor-Il
      remyelination.
    • NAICS/Industry Codes:
      NAICS/Industry Codes 112990 All Other Animal Production
    • Abstract:
      Insulin-like growth factors, IGF-I and IGF-II, play important roles in development and myelination in the CNS, but little is known about the response of IGF after demyelination. The present study investigated the expression of IGF and their cognitive receptors in the process of remyelination following ethidium bromide (EBr)-induced demyelination in the adult mouse spinal cord. The present results, in a quantitative real-time PCR, showed significant increases in the levels of the mRNA for both IGF-I and IGF-II during both the demyelination and remyelination stages. The levels of IGF-I receptor (IGF-IR) mRNA increased from 10 days to 4 weeks after the EBr injection. The levels of IGF-II receptor (IGF-IIR) mRNA decreased for 6 days and then increased 10 days after the EBr injection. In situ hybridization studies showed the cells expressing IGF-I mRNA to be mainly macrophage-like cells, while those expressing IGF-II mRNA were predominantly Schwann cell-like cells invading the demyelinating lesion. The immunoreactivity for the IGF-IR and IGF-IIR increased in various kinds of cells within and around the demyelinating lesions from 6 days to 4 weeks after the EBr injection. These results suggest that locally produced IGF could partly be involved in some mechanisms underlying remyelination processes following the EBr-induced demyelination in the mouse spinal cord. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Neuropathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • ISSN:
      09196544
    • Accession Number:
      14230517
  • Citations
    • ABNT:
      FUSHIMI, S.; SHIRABE, T. Expression of insulin-like growth factors in remyelination following ethidium bromide-induced demyelination in the mouse spinal cord. Neuropathology, [s. l.], v. 24, n. 3, p. 208, 2004. Disponível em: . Acesso em: 18 set. 2019.
    • AMA:
      Fushimi S, Shirabe T. Expression of insulin-like growth factors in remyelination following ethidium bromide-induced demyelination in the mouse spinal cord. Neuropathology. 2004;24(3):208. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=14230517. Accessed September 18, 2019.
    • APA:
      Fushimi, S., & Shirabe, T. (2004). Expression of insulin-like growth factors in remyelination following ethidium bromide-induced demyelination in the mouse spinal cord. Neuropathology, 24(3), 208. Retrieved from http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=14230517
    • Chicago/Turabian: Author-Date:
      Fushimi, Shigeko, and Teruo Shirabe. 2004. “Expression of Insulin-like Growth Factors in Remyelination Following Ethidium Bromide-Induced Demyelination in the Mouse Spinal Cord.” Neuropathology 24 (3): 208. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=14230517.
    • Harvard:
      Fushimi, S. and Shirabe, T. (2004) ‘Expression of insulin-like growth factors in remyelination following ethidium bromide-induced demyelination in the mouse spinal cord’, Neuropathology, 24(3), p. 208. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=14230517 (Accessed: 18 September 2019).
    • Harvard: Australian:
      Fushimi, S & Shirabe, T 2004, ‘Expression of insulin-like growth factors in remyelination following ethidium bromide-induced demyelination in the mouse spinal cord’, Neuropathology, vol. 24, no. 3, p. 208, viewed 18 September 2019, .
    • MLA:
      Fushimi, Shigeko, and Teruo Shirabe. “Expression of Insulin-like Growth Factors in Remyelination Following Ethidium Bromide-Induced Demyelination in the Mouse Spinal Cord.” Neuropathology, vol. 24, no. 3, Sept. 2004, p. 208. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=14230517.
    • Chicago/Turabian: Humanities:
      Fushimi, Shigeko, and Teruo Shirabe. “Expression of Insulin-like Growth Factors in Remyelination Following Ethidium Bromide-Induced Demyelination in the Mouse Spinal Cord.” Neuropathology 24, no. 3 (September 2004): 208. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=14230517.
    • Vancouver/ICMJE:
      Fushimi S, Shirabe T. Expression of insulin-like growth factors in remyelination following ethidium bromide-induced demyelination in the mouse spinal cord. Neuropathology [Internet]. 2004 Sep [cited 2019 Sep 18];24(3):208. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=14230517