脂肪因子，白细胞介素-6和肿瘤坏死因子-α水平与强直性脊柱炎患者骨密度相关性研究 (Chinese)

Correlation between the levels of adipokines, interleukin-6, and tumor necrosis factor-α and bone mineral density in patients with ankylosing spondylitis. (English)

Objective To identify correlations between the serum levels of leptin, adiponectin, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) and bone mineral density (BMD) in patients with ankylosing spondylitis (AS). Methods Forty-eight patients with AS were compared with 41 sex- and age-matched controls. The serum leptin, adiponectin, TNF-α, and IL-6 concentrations were determined. Body composition and BMD of the lumbar vertebrae (L1-L4) and femoral neck were evaluated using dual-energy X-ray absorptiometry. This study assessed the between the serum levels of adipokines, interleukin-6, and tumor necrosis factor-alpha and BMD in patients with AS. Results Patients with AS and controls had similar fat mass and lean mass. Serum interleukin-6, tumor necrosis factor-alpha, leptin, and adiponectin concentrations were significantly higher in AS patients than those in the control group. The levels of interleukin-6, tumor necrosis factor-alpha, leptin, and adiponectin in patients with osteoporosis (OP) were higher than those without OP; and the difference remained after adjusting for body mass index. Conclusion Elevated interleukin-6, tumor necrosis factor-a, leptin, and adiponectin concentrations are associated with reduction of BMD in patients with AS. [ABSTRACT FROM AUTHOR]

目的 探讨血清瘦素、脂联素、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平与强直性脊柱炎（AS）患者骨密度（BMD）的相关性。方法 将48例AS患者与41名性别和年龄匹配的对照组进行比较。测定血清瘦素、脂联素、TNF-α和IL-6水平。使用双能X射线吸收测定法评估腰椎（L1-L4）和股骨颈的BMD和身体组成。评估脂肪因子、白细胞介素-6和肿瘤坏死因子-α水平与强直性脊柱炎患者骨密度相关性。结果 AS患者和对照组具有相似的脂肪量和瘦体重。 AS患者的血清IL-6、TNF-α、瘦素和脂联素水平显著高于对照组。骨质疏松症（OP）患者的IL-6、TNF-α、瘦素和脂联素水平高于非OP的患者；在调整体质指数后，这种差异仍然存在。结论 AS患者的IL-6、TNF-α、瘦素和脂联素水平升高与BMD降低有关。 [ABSTRACT FROM AUTHOR]

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