补充双歧杆菌四联活菌片对糖尿病性骨质疏松患者骨 代谢指标影响的研究 (Chinese)

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    • Alternate Title:
      Study on the changes in levels of bone metabolic markers in diabetic osteoporosis patients after supplementation of Tetralogy of Viable Bifidobacterium tablet. (English)
    • Abstract:
      Objective To investigate the changes in levels of bone metabolic markers in type 2 diabetic osteoporosis patients after supplementation of Tetralogy of Viable Bifidobacterium tablet,and to explore whether supplementation of probiotics could improve bone metabolism and bone mineral density. Methods 200 patients with type 2 diabetic osteoporosis who were examined or hospitalized in the Endocrinology Department of our hospital from January 2016 to December 2017 were randomly divided into control group (100) and experimental group (100). Patients in the control group were given routine calcium and vitamin D treatment; patients in the experimental group were given calcium supplement and vitamin D plus bifidobacterium tetragenous viable bacteria tablets. Patients ’ osteocalcin,urinary calcium-creatinine ratio,total type I collagen amino-terminal extension of peptides, vitamin D and bone mineral density were observed after 3 months, 6 months and 12 months of treatment ( bone mineral density was measured after 12 months). Results The level of osteocalcin and bone mineral density increased significantly after supplementation of live Bifidobacterium tetrad,with statistical difference. After vitamin D supplementation,the level of vitamin D increased significantly with statistical difference. Conclusion Supplementation of Tetralogy of Viable Bifidobacterium tablet could improve bone mineral density in type 2 diabetic osteoporosis patients. [ABSTRACT FROM AUTHOR]
    • Abstract:
      目的 通过观察2 型糖尿病性骨质疏松患者补充双歧杆菌四联活菌片后骨代谢指标的变化ꎬ探讨补充益生菌是否能改 善骨代谢标志物及骨密度ꎮ 方法 选取2016 年1 月至2017 年12 月在我院内分泌科门诊检查或住院的2 型糖尿病性骨质疏 松患者200 例ꎬ随机分为对照组(100 名)与实验组(100 名)ꎮ 对照组患者采取常规补充钙剂及维生素D 治疗ꎻ实验组患者在 给予补充钙剂及维生素D 治疗基础上加用双歧杆菌四联活菌片治疗ꎮ 于治疗后3 个月、6 个月、12 个月后观察患者骨钙素、 尿钙肌酐比、总1 型胶原氨基端延长肽、维生素D 和骨密度(12 个月测1 次)的变化ꎮ 结果 补充双歧杆菌四联活菌后骨钙素 水平明显升高ꎬ骨密度明显升高ꎬ差异有统计学意义ꎮ 补充维生素D 后维生素D 水平明显升高ꎬ差异有统计学意义ꎮ 结论 补充双歧杆菌四联活菌片后ꎬ通过升高2 型糖尿病性骨质疏松患者的骨钙素水平改善了骨密度. [ABSTRACT FROM AUTHOR]
    • Abstract:
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