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Dengue in Western Uganda: a prospective cohort of children presenting with undifferentiated febrile illness.
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- Author(s): Boyce, Ross M.; Collins, Matthew; Muhindo, Rabbison; Nakakande, Regina; Ciccone, Emily J.; Grounds, Samantha; Espinoza, Daniel; Zhu, Yerun; Matte, Michael; Ntaro, Moses; Nyehangane, Dan; Juliano, Jonathan J.; Mulogo, Edgar M.
- Source:
BMC Infectious Diseases; 11/11/2020, Vol. 20 Issue 1, pN.PAG-N.PAG, 1p- Subject Terms:
DENGUE; DISEASES; MALARIA; DIAGNOSIS methods; SEROPREVALENCE; MALARIA diagnosis; DIAGNOSIS of fever; PROTOZOA; IMMUNOGLOBULINS; FLAVIVIRUSES; ENZYME-linked immunosorbent assay; DISEASE prevalence; RESEARCH funding; ROUTINE diagnostic tests; POLYMERASE chain reaction; EPIDEMIOLOGICAL research; LONGITUDINAL method - Source:
- Additional Information
- Subject Terms:
- Abstract:
Background: The spatial distribution and burden of dengue in sub-Saharan Africa remains highly uncertain, despite high levels of ecological suitability. The goal of this study was to describe the epidemiology of dengue among a cohort of febrile children presenting to outpatient facilities located in areas of western Uganda with differing levels of urbanicity and malaria transmission intensity.Methods: Eligible children were first screened for malaria using rapid diagnostic tests. Children with a negative malaria result were tested for dengue using a combination NS1/IgM/IgG rapid test (SD Bioline Dengue Duo). Confirmatory testing by RT-PCR was performed in a subset of participants. Antigen-capture ELISA was performed to estimate seroprevalence.Results: Only 6 of 1416 (0.42%) children had a positive dengue rapid test, while none of the RT-PCR results were positive. ELISA testing demonstrated reactive IgG antibodies in 28 (2.2%) participants with the highest prevalence seen at the urban site in Mbarara (19 of 392, 4.9%, p < 0.001).Conclusions: Overall, these findings suggest that dengue, while present, is an uncommon cause of non-malarial, pediatric febrile illness in western Uganda. Further investigation into the eocological factors that sustain low-level transmission in urban settings are urgently needed to reduce the risk of epidemics. [ABSTRACT FROM AUTHOR] - Abstract: Copyright of BMC Infectious Diseases is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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