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Effects of increasing intake of soybean oil on synthesis of testosterone in Leydig cells.
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- Author(s): Su, Yu; Tian, Zhenhua; Qi, Xiangyu; Luo, Dandan; Liu, Luna; Liu, Shuang; Zheng, Dongmei; Wei, Fang; He, Zhao; Guan, Qingbo
- Source:
Nutrition & Metabolism; 5/26/2021, Vol. 18 Issue 1, p1-10, 10p- Subject Terms:
TESTIS; ALPHA-linolenic acid; CYTOCHROME P-450; TESTOSTERONE; ANIMAL experimentation; CELL receptors; DIETARY supplements; COMPARATIVE studies; GAS chromatography; IMMUNOBLOTTING; SOY oil; ENZYME-linked immunosorbent assay; LINOLEIC acid; LUTEINIZING hormone; EPITHELIAL cells; POLYMERASE chain reaction; MICE; FATTY acids; CHORIONIC gonadotropins - Source:
- Additional Information
- Abstract: Background: Soybean oil is a very common edible oil in daily life. With the changes in the dietary composition, the intake of soybean oil increased. However, the effects of dietary intake of soybean oil on testosterone production are still unclear. Methods: In order to study the effects of increasing intake of soybean oil on the synthesis of testosterone in Leydig cells, we fed male C57BL/6 mice on the diet which added 20% soybean salad oil (SOY group). We detected the hormone levels by enzyme-linked immunosorbent assay (ELISA) kits and serum fatty acid composition by gas chromatography, and analyzed the expression of steroidogenic enzymes by Real-Time PCR or immunoblotting analysis. Results: After the 16-week feeding period, serum linoleic acid (LA) and α-linolenic acid (ALA) significantly increased and serum palmitic acid (PA) significantly decreased in SOY group mice. Compared to the normal diet (ND group), increasing intake of soybean oil raised the luteinizing hormone (LH) levels and up-regulated luteinizing hormone/chorionic gonadotropin receptor (LHCGR), steroidogenic acute regulatory protein (StAR) and cytochrome P450 family 11 subfamily A member I (CYP11A1). Testosterone levels in SOY group were higher than that in the ND group, and significantly difference showed. Conclusions: Increasing intake of soybean oil could raise the serum LA and ALA levels and decrease serum PA levels. This could activate the LH/LHCGR pathway and improve the function of steroid synthesis in Leydig cells, and finally lead to the elevated testosterone levels. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Nutrition & Metabolism is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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