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Aerobic Exercise-Assisted Cardiac Regeneration by Inhibiting Tryptase Release in Mast Cells after Myocardial Infarction.
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- Author(s): Bayat, Mohammad; Chien, Sufan; Chehelcheraghi, Farzaneh
- Source:
BioMed Research International; 6/8/2021, p1-9, 9p- Subject Terms:
HEART physiology; COLLAGEN; ECHOCARDIOGRAPHY; AEROBIC exercises; MYOCARDIUM; HEART cells; REGENERATION (Biology); ANIMAL experimentation; IMMUNOHISTOCHEMISTRY; MYOCARDIAL infarction; PROTEOLYTIC enzymes; FIBROSIS; HEALTH outcome assessment; RATS; COMPARATIVE studies; MAST cells; CARDIAC rehabilitation; DESCRIPTIVE statistics - Source:
- Additional Information
- Abstract: Background. Cardiovascular disease (CVD) contributes critically to the mortality, morbidity, and economic problem of illness globally. Exercise is a share of everyone's life. Some evidence-based studies have frequently shown a progressive correlation between physical activity and good health. Objective. The effects of daily exercise on cardiomyocyte size, collagen content (fibrosis), and releasing mast cells (MCsʼ) tryptase of the model of myocardial infarction (MI) were assessed. Methods. 40 rats were coincidentally spread into sham+inertia (control), sham+exercise, infarction+inertia, and infarction+exercise groups. An experimental model of acute MI was induced in infarction groups. One week after surgery, exercising groups were allowed to an aerobic exercise program for six weeks. At the endpoint of the study, all examinations were performed. Results. We found lesser fibrosis in sham+exercise and infarction+exercise groups compared to sham+inertia and infarction+inertia groups, respectively (p = 0.023 , p = 0.001). Also, infarction groups were significantly lower than sham groups (p < 0.05) and the infarction+exercise group was significantly lower than the infarction+inertia group (p < 0.05). The effect of exercise on MCs while increased MC density and degranulation occur at the site of fibrosis, we demonstrated that exercise decreases both total MC density and degranulation in both sham and infarction groups (p < 0.05). Immunohistochemistry examinations were significantly higher expression of MCsʼ tryptase in infarction groups than sham groups (p < 0.05 , p < 0.0001). Conclusion. Exercise improves fibrosis and cardiac function in both healthy and MI rats by inhibiting released MCsʼ tryptase. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of BioMed Research International is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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