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The Effect of Curcuma longa on Inflammatory Mediators and Immunological, Oxidant, and Antioxidant Biomarkers in Asthmatic Rats.
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- Author(s): Boskabady, Mohammad Hossein; Amin, Fatemeh; Shakeri, Farzaneh
- Source:
Evidence-based Complementary & Alternative Medicine (eCAM); 11/12/2021, p1-13, 13p, 7 Graphs- Subject Terms:
SULFUR compounds analysis; DRUG therapy for asthma; PROTEIN analysis; NITROGEN oxide analysis; IMMUNOGLOBULIN analysis; LUNG disease treatment; BIOMARKERS; INTERLEUKINS; EOSINOPHILS; BRONCHOALVEOLAR lavage; ANIMAL experimentation; LEUCOCYTES; DEXAMETHASONE; PHOSPHOLIPASES; ANTIOXIDANTS; OXIDIZING agents; SUPEROXIDE dismutase; RATS; INTERFERONS; MALONDIALDEHYDE; CATALASE; NEUTROPHILS; OXIDATIVE stress; COMPARATIVE studies; TREATMENT effectiveness; IMMUNOLOGICAL adjuvants; DESCRIPTIVE statistics; PLANT extracts; INFLAMMATORY mediators; IMMUNOLOGIC diseases; DATA analysis software; PHARMACODYNAMICS - Source:
- Additional Information
- Abstract: The effects of Curcuma longa (C. longa) on total and differential WBC, inflammatory and immunologic mediators, and oxidant and antioxidant biomarkers in bronchoalveolar lavage fluid (BALF) of rats model of asthma were assessed. Animals were divided to 5 groups including control (C), asthma (sensitized to ovalbumin), and asthmatic groups treated with 0.75, 1.50, and 3.00 mg/ml C. longa (CL) and 1.25 μg/ml dexamethasone (D) (8 rats in each group). Total and differential WBC count, concentrations of phospholipase A
2 (PLA2 ), total protein (TP), interferon-gamma (IFN-γ), interleukin-4 (IL-4), immunoglobulin E (IgE), NO2 , NO3 , malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and thiol in BALF were assessed. Total and most differential WBC counts and BALF levels of PLA2 , TP, IgE, IL-4, and oxidants in asthma group were higher but antioxidants and IFN-γ levels as well as IFN-γ/IL-4 ratio were lower than control group (p < 0.001 for all cases). Total WBC and levels of PLA2 , IgE, NO2 , and NO3 were significantly reduced following treatment with C. longa, compared to asthma group (p < 0.001 for all cases). In groups treated with dexamethasone and two higher concentrations of C. longa, neutrophil and eosinophil counts as well as TP, IL-4, and MDA levels were significantly decreased but IFN-γ, IFN-γ/IL-4 ratio, and antioxidants were increased (except IFN-γ/IL-4 ratio), compared to asthma group (p < 0.05 to p < 0.001). Compared to dexamethasone, C. longa exerted more pronounced effects on lung inflammation, oxidative stress, and immune system in asthmatic rats. [ABSTRACT FROM AUTHOR] - Abstract: Copyright of Evidence-based Complementary & Alternative Medicine (eCAM) is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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