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West Ashley Library
9 a.m. - 7 p.m.
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Folly Beach Library
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Functional nanovesicles displaying anti-PD-L1 antibodies for programmed photoimmunotherapy.
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- Author(s): Chen, Hu; Zhang, Pengfei; Shi, Yesi; Liu, Chao; Zhou, Qianqian; Zeng, Yun; Cheng, Hongwei; Dai, Qixuan; Gao, Xing; Wang, Xiaoyong; Liu, Gang
- Source:
Journal of Nanobiotechnology; 2/2/2022, Vol. 20 Issue 1, p1-15, 15p- Subject Terms:
- Source:
- Additional Information
- Abstract: Background: Photoimmunotherapy is one of the most promising strategies in tumor immunotherapies, but targeted delivery of photosensitizers and adjuvants to tumors remains a major challenge. Here, as a proof of concept, we describe bone marrow mesenchymal stem cell-derived nanovesicles (NVs) displaying anti-PD-L1 antibodies (aPD-L1) that were genetically engineered for targeted drug delivery. Results: The high affinity and specificity between aPD-L1 and tumor cells allow aPD-L1 NVs to selectively deliver photosensitizers to cancer tissues and exert potent directed photothermal ablation. The tumor immune microenvironment was programmed via ablation, and the model antigen ovalbumin (OVA) was designed to fuse with aPD-L1. The corresponding membrane vesicles were then extracted as an antigen–antibody integrator (AAI). AAI can work as a nanovaccine with the immune adjuvant R837 encapsulated. This in turn can directly stimulate dendritic cells (DCs) to boast the body's immune response to residual lesions. Conclusions: aPD-L1 NV-based photoimmunotherapy significantly improves the efficacy of photothermal ablation and synergistically enhances subsequent immune activation. This study describes a promising strategy for developing ligand-targeted and personalized cancer photoimmunotherapy. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Nanobiotechnology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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