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Antimicrobial activity, in vitro anticancer effect (MCF-7 breast cancer cell line), antiangiogenic and immunomodulatory potentials of Populus nigra L. buds extract.
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- Author(s): Kis, Brigitta; Pavel, Ioana Zinuca; Avram, Stefana; Moaca, Elena Alina; Herrero San Juan, Martina; Schwiebs, Anja; Radeke, Heinfried H.; Muntean, Delia; Diaconeasa, Zorita; Minda, Daliana; Oprean, Camelia; Bojin, Florina; Dehelean, Cristina Adriana; Soica, Codruta; Danciu, Corina
- Source:
BMC Complementary Medicine & Therapies; 3/16/2022, Vol. 22 Issue 1, p1-24, 24p, 2 Color Photographs, 2 Black and White Photographs, 6 Charts, 13 Graphs- Subject Terms:
PHENOL analysis; IN vitro studies; DENDRITIC cells; INTERLEUKINS; ESCHERICHIA coli; NEOVASCULARIZATION inhibitors; MEDICINAL plants; PHENOLS; STAINS & staining (Microscopy); DRUG dosage; CELL culture; IN vivo studies; PLANT anatomy; CANDIDA; ONE-way analysis of variance; ANTI-infective agents; ANTINEOPLASTIC agents; ANTIOXIDANTS; APOPTOSIS; FETAL membranes; PHYTOCHEMICALS; CELL survival; CELL cycle; STREPTOCOCCUS; INDICATOR dilution; IMMUNOASSAY; COMPARATIVE studies; IMMUNOLOGICAL adjuvants; DOSE-effect relationship in pharmacology; DESCRIPTIVE statistics; RESEARCH funding; STAPHYLOCOCCUS aureus; ENTEROCOCCUS; ENZYME-linked immunosorbent assay; FLUORESCENT antibody technique; CELL lines; PLANT extracts; FREE radical scavengers; INFRARED spectroscopy; PSEUDOMONAS; DATA analysis software; BREAST tumors; GRAM-positive bacteria; DRUG toxicity; CALORIMETRY; PHARMACODYNAMICS - Source:
- Additional Information
- Subject Terms:
- Abstract: Purpose: The aim of this study was to evaluate the antioxidant potential, antimicrobial activity, the in vitro anticancer effect (tested on MCF-7 breast cancer cell line), as well as the antiangiogenic and immunomodulatory potential of Populus nigra L. bud (Pg) extract collected from the western part of Romania. Results: Populus nigra L. bud extract presents an important antioxidant activity, due to the rich phytochemical composition. Regarding the biological activity, results have shown that poplar bud extract presents a significant inhibitory activity against Gram-positive bacteria and a dose-dependent decrease of MCF-7 tumor cell viability with an IC
50 of 66.26 μg/mL, while not affecting healthy cells. Phenomena of early apoptotic events at the maximum concentration tested (150 μg/mL) were detected by Annexin V-PI double staining. The extract induced G0/G1 phase cell cycle arrest. In addition, Pg extract showed antiangiogenic potential on the chorioallantoic membrane. Also, at the highest concentration (150 μg/mL), good tolerability and no signs of toxicity upon vascular plexus were observed. Moreover, in low concentrations, the Pg extract had immunomodulatory activity on primary human dendritic cells by upregulating IL-12 and IL-23 subunits. Conclusion: The study concludes that poplar bud extract elicited antioxidant activity, antitumor properties on the breast cancer cell line, followed by an antiangiogenic effect and an immunomodulatory potential on human primary dendritic cells. The biological activity of Populus nigra L. buds extract may open new directions of research on the topic addressed. [ABSTRACT FROM AUTHOR] - Abstract: Copyright of BMC Complementary Medicine & Therapies is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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