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Folly Beach Library
Closed for renovations
Phone: (843) 588-2001
John L. Dart Library
9 a.m. - 7 p.m.
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St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Mt. Pleasant Library
9 a.m. – 8 p.m.
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Dorchester Road Library
9 a.m. - 8 p.m.
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Main Library
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John's Island Library
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Wando Mount Pleasant Library
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Carbon Dioxide Reactivity of Brain Tissue Oxygenation after Pediatric Traumatic Brain Injury.
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- Author(s): Hanalioglu, Damla; Oh, Ann; Temkit, M'Hamed; Adelson, P. David; Appavu, Brian
- Source:
Children; Mar2022, Vol. 9 Issue 3, p409, 14p- Subject Terms:
BRAIN metabolism; STRUCTURAL equation modeling; BLOOD pressure; OXIMETRY; CONFIDENCE intervals; ACQUISITION of data methodology; CEREBRAL circulation; ARTERIES; RETROSPECTIVE studies; MANN Whitney U Test; INTRACRANIAL pressure; PEARSON correlation (Statistics); CARBON dioxide; MEDICAL records; DESCRIPTIVE statistics; GLASGOW Coma Scale; RESEARCH funding; BRAIN injuries; REACTIVE oxygen species; DATA analysis software; OXYGEN in the body; CHILDREN - Source:
- Additional Information
- Abstract: Background: We investigated how changes in partial pressure of brain tissue oxygenation (PbtO
2 ) relate to end-tidal carbon dioxide (EtCO2 ) after pediatric traumatic brain injury (TBI). Methods: Dynamic structural equation modeling (DSEM) was used to investigate associations between EtCO2 and PbtO2 , with positive associations indicating intact CO2 reactivity of PbtO2, and negative associations indicating impaired reactivity. Sub-analyses were performed to investigate associations of PbtO2 to intracranial pressure (ICP), arterial blood pressure (ABP) and cerebral regional oximetry (rSO2 ). Results: Among 14 patients, a positive association between PbtO2 and EtCO2 was demonstrated (SRC 0.05, 95% CI [0.04, 0.06]), with 9 patients demonstrating intact CO2 reactivity and 5 patients demonstrating impaired reactivity. Patients demonstrating intact CO2 reactivity had positive associations between PbtO2 and ICP (0.22 [0.21, 0.23]), whereas patients with impaired reactivity had negative associations (−0.28 [−0.29, −0.28]). Patients demonstrating intact CO2 reactivity had negative associations between PbtO2 and rSO2 (−0.08 [−0.09, −0.08]), whereas patients with impaired reactivity had positive associations (−0.15 [0.14, 0.16]). Compared to patients with intact CO2 reactivity, those with impaired reactivity had increased ICP (p < 0.0000), lower PbtO2 (p < 0.0000) and higher PRx (p = 0.0134). Conclusion: After TBI, CO2 reactivity of PbtO2 can be heterogenous, necessitating further work investigating factors contributing toward impaired reactivity. [ABSTRACT FROM AUTHOR] - Abstract: Copyright of Children is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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