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West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
Closed for renovations
Phone: (843) 588-2001
John L. Dart Library
9 a.m. – 7 p.m.
Phone: (843) 722-7550
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
Edgar Allan Poe/Sullivan's Island Library
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Main Library
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John's Island Library
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Edisto Library
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Wando Mount Pleasant Library
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Otranto Road Library
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Metabolic Pathways Associated With Psychoneurological Symptoms in Children With Cancer Receiving Chemotherapy.
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- Author(s): Bai, Jinbing; Withycombe, Janice; Eldridge, Ronald C.
- Source:
Biological Research for Nursing; Jul2022, Vol. 24 Issue 3, p281-293, 13p- Subject Terms:
CANCER pain; PILOT projects; COMPUTER adaptive testing; HODGKIN'S disease; METABOLOMICS; LIQUID chromatography; LYMPHOBLASTIC leukemia; OSTEOSARCOMA; METABOLISM; BLOOD collection; MANN Whitney U Test; TUMORS in children; CANCER patients; T-test (Statistics); CANCER fatigue; MENTAL depression; MASS spectrometry; DESCRIPTIVE statistics; RESEARCH funding; ANXIETY; DATA analysis software; LYMPHOMAS; METABOLITES - Source:
- Additional Information
- Abstract: Context: Children with cancer undergoing chemotherapy experience a cluster of psychoneurological symptoms (PNS), including pain, fatigue, anxiety, and depressive symptoms. Metabolomics is promising to differentiate metabolic pathways associated with the PNS cluster. Objectives: Identify metabolic pathways associated with the PNS cluster in children with cancer before and after chemotherapy. Methods: Pain, fatigue, anxiety, and depressive symptoms were assessed using the Pediatric PROMIS scales. T-scores were computed and divided dichotomously by a cutoff point of 50; the PNS cluster was a sum of the four symptoms ranging from 0 (all T-scores <50) to 4 (all T-scores ≥50). Serum metabolites were processed using liquid chromatography mass-spectrometry untargeted metabolomics approach. Linear regression models examined metabolites associated with the PNS cluster. Metabolic pathway enrichment analysis was performed. Results: Participant demographics (n = 40) were 55% female, 60% white, 62.5% aged 13–19 years, and 62.5% diagnoses of Hodgkin's lymphoma and B-cell acute lymphocytic leukemia. Among 9276 unique metabolic features, 454 were associated with pain, 281 with fatigue, 596 with anxiety, 551 with depressive symptoms, and 300 with the PNS cluster across one chemotherapy cycle. Fatty acids pathways were associated with pain: de novo fatty acid biosynthesis (p <.001), fatty acid metabolism (p =.001), fatty acid activation (p =.004), and omega-3 fatty acid metabolism (p =.009). Tryptophan amino acid pathway was associated with fatigue (p <.001), anxiety (p =.015), and the PNS cluster (p =.037). Carnitine shuttle was associated with the PNS cluster (p =.015). Conclusion: Fatty acids and amino acids pathways were associated with PNS in children undergoing chemotherapy. These findings require further investigation in a larger sample. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Biological Research for Nursing is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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