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West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
Closed for renovations
Phone: (843) 588-2001
John L. Dart Library
9 a.m. - 7 p.m.
Phone: (843) 722-7550
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Mt. Pleasant Library
9 a.m. – 8 p.m.
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Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
Edgar Allan Poe/Sullivan's Island Library
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Main Library
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John's Island Library
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Phone: (843) 884-9741
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The Big Picture of Neurodegeneration: A Meta Study to Extract the Essential Evidence on Neurodegenerative Diseases in a Network-Based Approach.
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- Author(s): Ruffini, Nicolas; Klingenberg, Susanne; Heese, Raoul; Schweiger, Susann; Gerber, Susanne
- Source:
Frontiers in Aging Neuroscience; 6/27/2022, Vol. 14, p1-36, 36p- Subject Terms:
ONLINE information services; ALZHEIMER'S disease; NEURONS; META-analysis; AUTOPHAGY; SYSTEMATIC reviews; APOPTOSIS; IMMUNE system; METABOLISM; PROTEOMICS; BIOINFORMATICS; CELL cycle; CELLULAR signal transduction; GENOMICS; GENE expression profiling; RESEARCH funding; PARKINSON'S disease; AMYOTROPHIC lateral sclerosis; HUNTINGTON disease; EXTRACELLULAR space; MEDLINE; NEURODEGENERATION; EPIGENOMICS - Source:
- Additional Information
- Abstract: The common features of all neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), and Huntington's disease, are the accumulation of aggregated and misfolded proteins and the progressive loss of neurons, leading to cognitive decline and locomotive dysfunction. Still, they differ in their ultimate manifestation, the affected brain region, and the kind of proteinopathy. In the last decades, a vast number of processes have been described as associated with neurodegenerative diseases, making it increasingly harder to keep an overview of the big picture forming from all those data. In this meta-study, we analyzed genomic, transcriptomic, proteomic, and epigenomic data of the aforementioned diseases using the data of 234 studies in a network-based approach to study significant general coherences but also specific processes in individual diseases or omics levels. In the analysis part, we focus on only some of the emerging findings, but trust that the meta-study provided here will be a valuable resource for various other researchers focusing on specific processes or genes contributing to the development of neurodegeneration. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Frontiers in Aging Neuroscience is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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