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Phone: (843) 805-6930
West Ashley Library
9 a.m. – 7 p.m.
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Folly Beach Library
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Phone: (843) 588-2001
John L. Dart Library
9 a.m. – 7 p.m.
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St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
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Mt. Pleasant Library
9 a.m. – 8 p.m.
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Wando Mount Pleasant Library
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Evaluation of the Delivery of a Live Attenuated Porcine Reproductive and Respiratory Syndrome Virus as a Unit Solid Dose Injectable Vaccine.
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- Author(s): Hayhurst, Ellie; Rose, Emily; Pedrera, Miriam; Edwards, Jane C.; Kotynska, Natalia; Grainger, Daisy; Sadigh, Yashar; Flannery, John; Bonnet, Ludo; Ritwik, Ritwik; Dulal, Pawan; Howard, M. Keith; Graham, Simon P.
- Source:
Vaccines; Nov2022, Vol. 10 Issue 11, p1836, 13p- Subject Terms:
- Source:
- Additional Information
- Abstract: Solid dose vaccine formulation and delivery systems offer potential advantages over traditional liquid vaccine formulations. In addition to enhanced thermostability, needle-free delivery of unit solid dose injectable (USDI) vaccines offers safe, rapid, and error-free administration, with applicability to both human and animal health. Solid dose formulation technologies can be adapted for delivery of different vaccine formats including live attenuated vaccines, which remain the 'gold standard' for many disease targets. Porcine reproductive and respiratory syndrome viruses (PRRSV) cause one of the most economically important diseases affecting the global pig industry. Despite several shortcomings, live attenuated vaccines are widely used to control PRRSV. We optimised a freeze-dried USDI formulation of live attenuated PRRSV-1, which fully retained infectious titre, and evaluated its immunogenicity in comparison to virus delivered in liquid suspension via intramuscular and subcutaneous needle inoculation. Pigs vaccinated with the USDI formulation displayed vaccine viraemia, and PRRSV-specific antibody and T cell responses comparable to animals immunised with the liquid vaccine. The USDI vaccine formulation was stable for at least 6 months when stored refrigerated. These data demonstrate the potential for a solid dose vaccine delivery system as an alternative to conventional needle-syringe delivery of live attenuated PRRSV vaccines. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Vaccines is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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