Lysosomal system pathways: Genes to neurodegeneration in Alzheimer's disease.

Item request has been placed! ×
Item request cannot be made. ×
  Processing Request
  • Additional Information
    • Publication Year:
      2006
    • Author-Supplied Keywords:
      Alzheimer's disease
      Amyloid-β
      Amyloid-β
      apoptosis
      autophagy
      cathepsin
      endocytosis
      endosome
      necrosis
      protease
    • Abstract:
      The identification of cathepsins in amyloid-β plaques revealed broad dysfunction of the lysosomal system in Alzheimer's disease (AD). Coinciding with the discovery that proteolysis is required to generate the Aβ-peptide, these findings heralded an era of intense investigation on proteases in neurodegeneration. This review traces lysosomal system pathology from its early characterization to its origins within two pathways leading to the lysosome, the endocytic and autophagic pathways. An understanding has grown about how these two pathways are adversely influenced by normal brain aging and by genetic and environmental risk factors for AD, resulting in increased susceptibility of neurons to injury, amyloidogenesis, and neurodegeneration. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Journal of Alzheimer's Disease is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • ISSN:
      13872877
    • Accession Number:
      22083670
  • Citations
    • ABNT:
      NIXON, R. A.; CATALDO, A. M. Lysosomal system pathways: Genes to neurodegeneration in Alzheimer’s disease. Journal of Alzheimer’s Disease, [s. l.], v. 9, n. 3, p. 277, 2006. Disponível em: . Acesso em: 24 ago. 2019.
    • AMA:
      Nixon RA, Cataldo AM. Lysosomal system pathways: Genes to neurodegeneration in Alzheimer’s disease. Journal of Alzheimer’s Disease. 2006;9(3):277. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=22083670. Accessed August 24, 2019.
    • APA:
      Nixon, R. A., & Cataldo, A. M. (2006). Lysosomal system pathways: Genes to neurodegeneration in Alzheimer’s disease. Journal of Alzheimer’s Disease, 9(3), 277. Retrieved from http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=22083670
    • Chicago/Turabian: Author-Date:
      Nixon, Ralph A., and Anne M. Cataldo. 2006. “Lysosomal System Pathways: Genes to Neurodegeneration in Alzheimer’s Disease.” Journal of Alzheimer’s Disease 9 (3): 277. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=22083670.
    • Harvard:
      Nixon, R. A. and Cataldo, A. M. (2006) ‘Lysosomal system pathways: Genes to neurodegeneration in Alzheimer’s disease’, Journal of Alzheimer’s Disease, 9(3), p. 277. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=22083670 (Accessed: 24 August 2019).
    • Harvard: Australian:
      Nixon, RA & Cataldo, AM 2006, ‘Lysosomal system pathways: Genes to neurodegeneration in Alzheimer’s disease’, Journal of Alzheimer’s Disease, vol. 9, no. 3, p. 277, viewed 24 August 2019, .
    • MLA:
      Nixon, Ralph A., and Anne M. Cataldo. “Lysosomal System Pathways: Genes to Neurodegeneration in Alzheimer’s Disease.” Journal of Alzheimer’s Disease, vol. 9, no. 3, June 2006, p. 277. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=22083670.
    • Chicago/Turabian: Humanities:
      Nixon, Ralph A., and Anne M. Cataldo. “Lysosomal System Pathways: Genes to Neurodegeneration in Alzheimer’s Disease.” Journal of Alzheimer’s Disease 9, no. 3 (June 2, 2006): 277. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=22083670.
    • Vancouver/ICMJE:
      Nixon RA, Cataldo AM. Lysosomal system pathways: Genes to neurodegeneration in Alzheimer’s disease. Journal of Alzheimer’s Disease [Internet]. 2006 Jun 2 [cited 2019 Aug 24];9(3):277. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edb&AN=22083670