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Main Library
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Folly Beach Library
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John L. Dart Library
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Comparing Reconstruction With Ileocecal Graft to Jejunal Interposition Pouch After Total Gastrectomy in Rats.
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- Author(s): Medeiros, Aldo Cunha; Filho, Irami Araújo; Medeiros, Vítor Brasil; Pinheiro, Laíza Araújo Mohana; Freire, Flávio Henrique Miranda Araújo; Azevedo, Ítalo Medeiros; Brandão-Neto, José
- Source:
Journal of Investigative Surgery; Jan/Feb2007, Vol. 20 Issue 1, p41-48, 8p, 4 Charts, 3 Graphs- Subject Terms:
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- Abstract: After total gastrectomy, the ileocecal graft may act as a reservoir and protect against reflux but give rise to transposition of the ileum and cause possible changes in bile acid metabolism and nutrition. This study compared the ileocecal graft and jejunal pouch. Male Wistar rats weighing 265 ± 22 g were submitted to sham operation (S), ileocecal interposition graft (IIG), and jejunal pouch interposition graft (JP) after total gastrectomy. Eight weeks later, the esophagus was examined for evidence of esophagitis. Nutritional biochemistry and weight profile were documented preoperatively and 8 weeks after surgery. The oral glucose tolerance test was performed. Thirty-three rats were operated on and 30 survived for 8 weeks. Esophagitis occurred in seven JP rats. Body weight was significantly higher in IIG than in JP rats (p < .05). Normal glucose tolerance to intragastric glucose load was observed in sham and operated rats. JP rats had a significant decrease in serum albumin, glucose, transferrin, hemoglobin, iron, folate, and calcium, compared to sham (p < .05). Cobalamine was significantly lower in IIG rats than in JP rats (p < .05). In the IIG and JP groups, serum/hepatic total bile acid did not differ significantly from preoperative and sham values. In conclusion, the IIG interposition graft in rats prevented esophagitis, preserved nutrition, and did not interfere with enterohepatic total bile acid circulation. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Investigative Surgery is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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