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Biomarkers for the Diagnosis, Prognosis, and Evaluation of Treatment Efficacy for Traumatic Brain Injury
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- Author(s): Dash, Pramod K.; Zhao, Jing; Hergenroeder, Georgene; Moore, Anthony N.
- Source:
Neurotherapeutics; Jan2010, Vol. 7 Issue 1, p100-114, 15p- Subject Terms:
BRAIN injury diagnosis; BIOMARKERS; BRAIN diseases; TREATMENT effectiveness; LOSS of consciousness; INTRACRANIAL pressure; AXONS; MORTALITY; PROGNOSIS; BRAIN injury treatment; ANIMAL experimentation; BRAIN injuries; COMPARATIVE studies; DIFFERENTIAL diagnosis; RESEARCH methodology; MEDICAL cooperation; RESEARCH; RESEARCH funding; EVALUATION research; DIAGNOSIS - Source:
- Additional Information
- Abstract: Summary: Traumatic brain injury (TBI) remains a serious health concern, and TBI is one of the leading causes of death and disability, especially among young adults. Although preventive education, increased usage of safety devices, and TBI management have dramatically increased the potential for surviving a brain injury, there is still a need to develop reliable methods to diagnose TBI, the secondary pathologies associated with TBI, and predicting the outcomes of TBI. Biomarkers (changes of amount or activity in a biomolecule that reflect injury or disease) have shown promise in the diagnosis of several conditions, including cancer, heart failure, infection, and genetic disorders. A variety of proteins, small molecules, and lipid products have been proposed as potential biomarkers of brain damage from TBI. Although some of these changes have been reported to correlate with mortality and outcome, further research is required to identify prognostic biomarkers. This need is punctuated in mild injuries that cannot be readily detected using current techniques, as well as in defining patient risk for developing TBI-associated secondary injuries. [Copyright &y& Elsevier]
- Abstract: Copyright of Neurotherapeutics is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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