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Erythrocyte aggregation portends worse outcomes in unstable angina patients undergoing percutaneous coronary interventions.
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- Author(s): Steinvil, Arie; Arbel, Yaron; Leshem-Rubinow, Eran; Halkin, Amir; Keren, Gad; Revivo, Miri; Finkelstein, Ariel; Cohen, Merav; Tal, Ruth; Aviram, Galit; Berliner, Shlomo; Banai, Shmuel
- Source:
Clinical Hemorheology & Microcirculation; 2013, Vol. 55 Issue 2, p213-221, 9p- Subject Terms:
- Source:
- Additional Information
- Abstract: OBJECTIVE: The positive correlation between the time from symptom onset to the appearance of an inflammatory response and erythrocyte aggregation (EA) in the peripheral blood of acute coronary syndromes (ACS) patients had been previously reported by us. We now analyze the added prognostic value of EA in ACS patients undergoing percutaneous coronary interventions (PCI). METHODS: We performed an analysis on prospectively collected data at a tertiary hospital catheterization laboratory between 2006-2011. Cox regression models were fitted for EA cut-offs and performed separately for myocardial infarction (MI) and unstable angina pectoris (UAP) patients. Major adverse cardiovascular events (MACE) were defined as all-cause mortality, MI and stroke. Follow up time was defined as the time from PCI to either MACE or November 20, 2011. RESULTS: Included were 1055 patients (637 with MI and 418 with UAP). The median follow up in the MI and the UAP groups was 14 and 15 months, respectively (maximal follow up of 4.1 years). In the UAP group there was a significant increase in the MACE for the group with high EA (HR = 2.3, p = 0.04) compared to the group of patients with low EA. This was not found for patients presenting with MI. CONCLUSIONS: Elevated EA portends worse outcomes in UAP patients undergoing PCI. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Clinical Hemorheology & Microcirculation is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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