Extended follow-up of the CYCLOFA-LUNE trial comparing two sequential induction and maintenance treatment regimens for proliferative lupus nephritis based either on cyclophosphamide or on cyclosporine A.

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    • Abstract:
      The article examines the extended follow-up of the CYLOFA-LUNE randomized controlled trial that compares two sequential proliferative lupus nephritis induction and maintenance treatments based on cyclosporine A (CyA) or cyclophosphamide (CPH). The study shows no difference on the end-stage renal disease and renal impairment rates between CyA and CPH. The similar long term clinical results between CPH and CyA are also noted.