Essential Oil of Alpinia calcarataRosc. Rhizome: Heals Inflammation and Nociception in Animal models

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    • Abstract:
      AbstractEssential oil of Alpinia calcarataRosc. rhizome was studied for anti-inflammatory and anti-nociceptive effects in animal models. Anti-inflammatory effect was investigated in carrageenan-induced paw edema model in Albino rat with the doses of 100, 200 and 400 mg/kg BW. Anti-nociceptive effect was measured in acetic acid-induced pain, formalin-induced pain and thermal pain (hot plate test) models in Albino mice with the doses of 200, 400 and 600 mg/kg BW. Significant (p<0.05) inhibition (63.82 ± 1.27%) of paw edema compared to diclofenac sodium was achieved by 200 mg/kg of essential oil. Nociception in acetic acid-induced writhing model and pain in formalin-induced model were also reduced by essential oil (400 mg/kg) significantly compared to reference drugs diclofenac sodium and morphine, respectively. Essential oil (400 mg/kg) reduced the thermal pain in early and late phases of hot plate model significantly compared to morphine. Maximum possible effect (%MPE) for essential oil was achieved by 600 mg/kg at the 60thmin of treatment in hot plate model. Results evidenced that essential oil from Alpinia calcaratacould be processed to use as an alternative source of inflammatory and nociceptive treatment.