A prospective, multi-center study of Candida bloodstream infections in Chile

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  • Additional Information
    • Publication Information:
      Public Library of Science
    • Publication Date:
      2019
    • Subject Terms:
    • Abstract:
      Background Active surveillance is necessary for improving the management and outcome of patients with candidemia. The aim of this study was to describe epidemiologic and clinical features of candidemia in children and adults in tertiary level hospitals in Chile. Methods We conducted a prospective, multicenter, laboratory-based survey study of candidemia in 26 tertiary care hospitals in Chile, from January 2013 to October 2017. Results A total of 780 episodes of candidemia were included, with a median incidence of 0.47/1,000 admissions. Demographic, clinical and microbiological information of 384 cases of candidemia, from 18 hospitals (7,416 beds), was included in this report. One hundred and thirty-four episodes (35%) occurred in pediatric patients and 250 (65%) in adult population. Candida albicans (39%), Candida parapsilosis (30%) and Candida glabrata (10%) were the leading species, with a significant difference in the distribution of species between ages. The use of central venous catheter and antibiotics were the most frequent risk factors in all age groups (> 70%). Three hundred and fifteen strains were studied for antifungal susceptibility; 21 strains (6.6%) were resistant to fluconazole, itraconazole, voriconazole, anidulafungin or micafungin. The most commonly used antifungal therapies were fluconazole (39%) and echinocandins (36%). The overall 30-day survival was 74.2%, significantly higher in infants (82%) and children (86%) compared with neonates (72%), adults (71%) and elderly (70%). Conclusions Our prospective, multicenter surveillance study showed a low incidence of candidemia in Chile, with high 30-day survival, a large proportion of elderly patients, C. glabrata as the third most commonly identified strain, a 6.6% resistance to antifungal agents and a frequent use of echinocandins.
    • ISSN:
      1932-6203
    • Rights:
      COPYRIGHT 2019 Public Library of Science
      Copyright 2019 Gale, Cengage Learning. All rights reserved.
    • Accession Number:
      edsgcl.577623270
  • Citations
    • ABNT:
      SANTOLAYA, M. E. et al. A prospective, multi-center study of Candida bloodstream infections in Chile. PLoS ONE, [s. l.], n. 3, 2019. Disponível em: . Acesso em: 17 ago. 2019.
    • AMA:
      Santolaya ME, Thompson L, Benadof D, et al. A prospective, multi-center study of Candida bloodstream infections in Chile. PLoS ONE. 2019;(3). http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsgov&AN=edsgcl.577623270. Accessed August 17, 2019.
    • APA:
      Santolaya, M. E., Thompson, L., Benadof, D., Tapia, C., Legarraga, P., Cortes, C., … Rabagliati, R. (2019). A prospective, multi-center study of Candida bloodstream infections in Chile. PLoS ONE, (3). Retrieved from http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsgov&AN=edsgcl.577623270
    • Chicago/Turabian: Author-Date:
      Santolaya, Maria E., Luis Thompson, Dona Benadof, Cecilia Tapia, Paulette Legarraga, Claudia Cortes, Marcela Rabello, Romina Valenzuela, Pamela Rojas, and Ricardo Rabagliati. 2019. “A Prospective, Multi-Center Study of Candida Bloodstream Infections in Chile.” PLoS ONE, no. 3. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsgov&AN=edsgcl.577623270.
    • Harvard:
      Santolaya, M. E. et al. (2019) ‘A prospective, multi-center study of Candida bloodstream infections in Chile’, PLoS ONE, (3). Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsgov&AN=edsgcl.577623270 (Accessed: 17 August 2019).
    • Harvard: Australian:
      Santolaya, ME, Thompson, L, Benadof, D, Tapia, C, Legarraga, P, Cortes, C, Rabello, M, Valenzuela, R, Rojas, P & Rabagliati, R 2019, ‘A prospective, multi-center study of Candida bloodstream infections in Chile’, PLoS ONE, no. 3, viewed 17 August 2019, .
    • MLA:
      Santolaya, Maria E., et al. “A Prospective, Multi-Center Study of Candida Bloodstream Infections in Chile.” PLoS ONE, no. 3, 2019. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsgov&AN=edsgcl.577623270.
    • Chicago/Turabian: Humanities:
      Santolaya, Maria E., Luis Thompson, Dona Benadof, Cecilia Tapia, Paulette Legarraga, Claudia Cortes, Marcela Rabello, Romina Valenzuela, Pamela Rojas, and Ricardo Rabagliati. “A Prospective, Multi-Center Study of Candida Bloodstream Infections in Chile.” PLoS ONE, no. 3 (2019). http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsgov&AN=edsgcl.577623270.
    • Vancouver/ICMJE:
      Santolaya ME, Thompson L, Benadof D, Tapia C, Legarraga P, Cortes C, et al. A prospective, multi-center study of Candida bloodstream infections in Chile. PLoS ONE [Internet]. 2019 [cited 2019 Aug 17];(3). Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsgov&AN=edsgcl.577623270