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Fetal Therapy for Down Syndrome: Report of Three Cases and a Review of the Literature.
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- Author(s): Baggot, Patrick James (Paddy Jim) (AUTHOR); Baggot, Rocel Medina (AUTHOR)
- Source:
Issues in Law & Medicine. Spring2017, Vol. 32 Issue 1, p31-41. 11p. - Source:
- Additional Information
- Subject Terms:
- Abstract: Background: Down syndrome (trisomy 21) is a well-known cause of mental retardation. It can be diagnosed in early pregnancy. Scientists have made great strides in outlining the pathophysiologic mechanisms of mental retardation in Down syndrome. Much less has been published on human therapy. To cur knowledge, these are the first published cases of fetal therapy for Down syndrome. Methodology: Reports of three cases. In all cases, treatment was both biochemical (e.g. nutritional) and educational. In all cases, treatment was both befcre and after birth. Results: All children lacked the characteristic faces usually seen in the children with Down syndrome. This suggests a treatment effect before birth. All children had better than expected development. Discussion: Enhancement of development is preposed as a new therapeutic principle. Developing neurons exchange neurotrophic factors during development when they give or receive stimulation from other neurons. Neurons which receive neurotrophic stimulation survive, and those, which do not, are lost to apoptosis. The developmental therapeutic principle seeks to optimize brain development. Biochemical inputs (neurotransmitters, drugs, hormones, nutrients) and functional stimulation are integrated to optimize the growth and survival of neurons individually; other cells; subcellular organelles; and the brain as a whole. Treatment may be before and after birth, both biochemical and functional. These principles may be applied to Down syndrome, other conditions, and normal fetuses or children. Previously published: Baggot PJ and Baggot RM (2014). Fetal Therapy for Down Syndrome: Report of three cases and review of the literature. J Am Phys Surg 19(l):20-24. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Issues in Law & Medicine is the property of Issues in Law & Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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