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9 a.m. - 8 p.m.
Phone: (843) 805-6930
West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
Closed for renovations
Phone: (843) 588-2001
John L. Dart Library
9 a.m. – 7 p.m.
Phone: (843) 722-7550
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
Dorchester Road Library
9 a.m. - 8 p.m.
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John's Island Library
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Wando Mount Pleasant Library
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Randomized Trial of 2 Schedules of Meningococcal B Vaccine in Adolescents and Young Adults, Canada1.
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- Author(s): Langley, Joanne M.; Gantt, Soren; Quach, Caroline; Bettinger, Julie A.; Halperin, Scott A.; Mutch, Jill; McNeil, Shelly A.; Ward, Brian J.; MacKinnon-Cameron, Donna; Ye, Lingyun; Marty, Kim; Scheifele, David; Brown, Erin; Alcantara, Joenel; Canadian Immunization Research Network (CORPORATE AUTHOR)
- Source:
Emerging Infectious Diseases. Mar2020, Vol. 26 Issue 3, p454-462. 9p. - Source:
- Additional Information
- Subject Terms: MENINGOCOCCAL vaccines; YOUNG adults; IMMUNIZATION of children; MENINGOCOCCAL infections; NEISSERIA meningitidis; TEENAGERS; ANTI-vaccination movement; PREVENTION of epidemics; RESEARCH; IMMUNIZATION; MEDICAL care for teenagers; RESEARCH methodology; MEDICAL cooperation; EVALUATION research; MEDICAL protocols; COMPARATIVE studies; RANDOMIZED controlled trials; STUDENTS; GRAM-negative aerobic bacteria; UNIVERSITIES & colleges; BLIND experiment; RESEARCH funding; STATISTICAL sampling
- Subject Terms:
- Abstract: Emergency vaccination programs often are needed to control outbreaks of meningococcal disease caused by Neisseria meningitidis serogroup B (MenB) on college campuses. Such campaigns expend multiple campus and public health resources. We conducted a randomized, controlled, multicenter, observer-blinded trial comparing immunogenicity and tolerability of an accelerated vaccine schedule of 0 and 21 days to a longer interval of 0 and 60 days for 4-component MenB vaccine (MenB-4C) in students 17-25 years of age. At day 21 after the first MenB-4C dose, we observed protective human serum bactericidal titers >4 to MenB strains 5/99, H44/76, and NZ 98/254 in 98%-100% of participants. Geometric mean titers increased >22-fold over baseline. At day 180, >95% of participants sustained protective titers regardless of their vaccine schedule. The most common adverse event was injection site pain. An accelerated MenB-4C immunization schedule could be considered for rapid control of campus outbreaks. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Emerging Infectious Diseases is the property of Centers for Disease Control & Prevention (CDC) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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