ICOS co-stimulatory receptor is essential for T-cell activation and function.

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    • Subject Terms:
      T cell receptors; GENETICS of autoimmune diseases; LABORATORY mice; INTERLEUKIN-4; GENETICS
    • Abstract:
      Shows that T-cell activation and proliferation are defective in the absence of inducible co-stimulatory molecule (ICOS). Generation and analysis of ICOS-deficient mice to understand the role of ICOS in T-cell activation; Failure of cells to produce interleukin-4 when differentiated in vitro or when primed in vivo; Indication that ICOS has a protective role in inflammatory autoimmune diseases.