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Effects of Nitric Oxide and Noradrenergic Function on Skin Electric Resistance of Acupoints and Meridians.
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- Author(s): Jia-Xu Chen; Sheng-Xing Ma
- Source:
Journal of Alternative & Complementary Medicine. Jun2005, Vol. 11 Issue 3, p423-431. 9p. - Source:
- Additional Information
- Subject Terms:
- Abstract: Objectives: The objectives of this study were to determine the effects of L-arginine–derived nitric oxide (NO) synthesis and noradrenergic function on skin electrical resistance of acupoints and meridians. Design: Experiments were performed on male Sprague-Dawley rats anesthetized with sodium pentobarbital. Low skin-resistance points (LSRP; BL 56, PC 6, CV 17), non-LSRP positions (along the meridians), and non- LSRP, non-meridian control positions (adjacent to but not along the meridians) were determined on the skin surface by measurements of the skin stimulus-evoked electrical currents. The effects of L-arginine–derived NO synthesis and noradrenergic function on the currents, representing skin electrical resistance, were examined in the LSRP, non-LSRP, and non-meridian control points. Results: The skin stimulus–evoked electrical currents at BL 56 (36.4 ± 1.4 µA), PC 6 (35.4 ± 1.2), and CV 17 (33.1 ± 1.4) were significantly higher than those in non-LSRP and non-meridian control positions ( p < 0.01, n = 7). The currents were consistently increased after repeated stimulation along the skin as a function of time. Intravenous injections of L-arginine (3 mg/kg, 10 mg/kg, and 30 mg/kg) and 3-morpholinyl-sydnoneimine (SIN-1; 1 µg/kg, 3 µg/kg, and 10 µg/kg) produced dose-dependent increases in the currents ( p < 0.05, n = 5–6), but currents were not altered by injections of D-arginine (3 mg/kg, 10 mg/kg, and 30 mg/kg). Stimulus-evoked increases in currents were blocked by intravenous injections of either N G-propyl-L-arginine (NPLA, 3 mg/kg), N-nitro-L-arginine methyl ester (L-NAME, 10 mg/kg), or guanethidine (3 mg/kg), a noradrenergic blockade. Conclusions: This is the first evidence showing that L-arginine–derived NO synthesis and noradrenergic transmission modify the skin electric conductance of LSRP. L-Arginine–derived NO synthesis appears to mediate noradrenergic function on skin sympathetic nerve activation, which contributes to low resistance characteristics of acupoints and meridians. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Alternative & Complementary Medicine is the property of Mary Ann Liebert, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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