Blood Pressure, Left Ventricular Geometry, and Systolic Function in Children Exposed to Inorganic Arsenic.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Subject Terms:
    • Subject Terms:
    • Abstract:
      Background: Inorganic arsenic (iAs) is a ubiquitous element present in the groundwater worldwide. Cardiovascular effects related to iAs exposure have been studied extensively in adult populations. Few epidemiological studies have been focused on iAs exposure–related cardiovascular disease in children. Objective: In this study we investigated the association between iAs exposure, blood pressure (BP), and functional and anatomical echocardiographic parameters in children. Methods: A cross-sectional study of 161 children between 3 and 8 years was conducted in Central Mexico. The total concentration of arsenic (As) species in urine (U-tAs) was determined by hydride generation-cryotrapping-atomic absorption spectrometry and lifetime iAs exposure was estimated by multiplying As concentrations measured in drinking water by the duration of water consumption in years (LAsE). BP was measured by standard protocols, and M-mode echocardiographic parameters were determined by ultrasonography. Results: U-tAs concentration and LAsE were significantly associated with diastolic (DBP) and systolic blood pressure (SBP) in multivariable linear regression models: DBP and SBP were 0.013 (95% CI: 0.002, 0.024) and 0.021 (95% CI: 0.004, 0.037) mmHg higher in association with each 1-ng/mL increase in U-tAs (p < 0.025), respectively. Left ventricular mass (LVM) was significantly associated with LAsE [5.5 g higher (95% CI: 0.65, 10.26) in children with LAsE > 620 compared with < 382 μg/L-year; p = 0.03] in an adjusted multivariable model. The systolic function parameters left ventricular ejection fraction (EF) and shortening fraction were 3.67% (95% CI: -7.14, -0.20) and 3.41% (95% CI: -6.44, -0.37) lower, respectively, in children with U-tAs > 70 ng/mL compared with < 35 ng/mL. Conclusion: Early-life exposure to iAs was significantly associated with higher BP and LVM and with lower EF in our study population of Mexican children. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Environmental Health Perspectives is the property of Superintendent of Documents and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • Full Text Word Count:
      7740
    • ISSN:
      0091-6765
    • Accession Number:
      10.1289/ehp.1307327
    • Accession Number:
      103119686
  • Citations
    • ABNT:
      OSORIO-YÁÑEZ, C. et al. Blood Pressure, Left Ventricular Geometry, and Systolic Function in Children Exposed to Inorganic Arsenic. Environmental Health Perspectives, [s. l.], v. 123, n. 6, p. 629–635, 2015. DOI 10.1289/ehp.1307327. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hxh&AN=103119686. Acesso em: 16 fev. 2020.
    • AMA:
      Osorio-Yáñez C, Ayllon-Vergara JC, Arreola-Mendoza L, et al. Blood Pressure, Left Ventricular Geometry, and Systolic Function in Children Exposed to Inorganic Arsenic. Environmental Health Perspectives. 2015;123(6):629-635. doi:10.1289/ehp.1307327.
    • APA:
      Osorio-Yáñez, C., Ayllon-Vergara, J. C., Arreola-Mendoza, L., Aguilar-Madrid, G., Hernández-Castellanos, E., Sánchez-Peña, L. C., & Del Razo, L. M. (2015). Blood Pressure, Left Ventricular Geometry, and Systolic Function in Children Exposed to Inorganic Arsenic. Environmental Health Perspectives, 123(6), 629–635. https://doi.org/10.1289/ehp.1307327
    • Chicago/Turabian: Author-Date:
      Osorio-Yáñez, Citlalli, Julio C. Ayllon-Vergara, Laura Arreola-Mendoza, Guadalupe Aguilar-Madrid, Erika Hernández-Castellanos, Luz C. Sánchez-Peña, and Luz M. Del Razo. 2015. “Blood Pressure, Left Ventricular Geometry, and Systolic Function in Children Exposed to Inorganic Arsenic.” Environmental Health Perspectives 123 (6): 629–35. doi:10.1289/ehp.1307327.
    • Harvard:
      Osorio-Yáñez, C. et al. (2015) ‘Blood Pressure, Left Ventricular Geometry, and Systolic Function in Children Exposed to Inorganic Arsenic’, Environmental Health Perspectives, 123(6), pp. 629–635. doi: 10.1289/ehp.1307327.
    • Harvard: Australian:
      Osorio-Yáñez, C, Ayllon-Vergara, JC, Arreola-Mendoza, L, Aguilar-Madrid, G, Hernández-Castellanos, E, Sánchez-Peña, LC & Del Razo, LM 2015, ‘Blood Pressure, Left Ventricular Geometry, and Systolic Function in Children Exposed to Inorganic Arsenic’, Environmental Health Perspectives, vol. 123, no. 6, pp. 629–635, viewed 16 February 2020, .
    • MLA:
      Osorio-Yáñez, Citlalli, et al. “Blood Pressure, Left Ventricular Geometry, and Systolic Function in Children Exposed to Inorganic Arsenic.” Environmental Health Perspectives, vol. 123, no. 6, June 2015, pp. 629–635. EBSCOhost, doi:10.1289/ehp.1307327.
    • Chicago/Turabian: Humanities:
      Osorio-Yáñez, Citlalli, Julio C. Ayllon-Vergara, Laura Arreola-Mendoza, Guadalupe Aguilar-Madrid, Erika Hernández-Castellanos, Luz C. Sánchez-Peña, and Luz M. Del Razo. “Blood Pressure, Left Ventricular Geometry, and Systolic Function in Children Exposed to Inorganic Arsenic.” Environmental Health Perspectives 123, no. 6 (June 2015): 629–35. doi:10.1289/ehp.1307327.
    • Vancouver/ICMJE:
      Osorio-Yáñez C, Ayllon-Vergara JC, Arreola-Mendoza L, Aguilar-Madrid G, Hernández-Castellanos E, Sánchez-Peña LC, et al. Blood Pressure, Left Ventricular Geometry, and Systolic Function in Children Exposed to Inorganic Arsenic. Environmental Health Perspectives [Internet]. 2015 Jun [cited 2020 Feb 16];123(6):629–35. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hxh&AN=103119686