Prenatal Exposure to Phthalates and the Development of Eczema Phenotypes in Male Children: Results from the EDEN Mother-Child Cohort Study.

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    • Subject Terms:
    • Abstract:
      BACKGROUND: Contradictory results exist regarding the importance of early-life exposure to phthalates for development of childhood eczema. OBJECTIVES: We evaluated the association between maternal urinary concentrations of phthalate metabolites between the 24th and 28th week of gestation and occurrence of eczema in their sons up to 5 y of age, according to allergic sensitization as assessed by total immunoglobulin E (IgE) in a subsample of individuals. METHODS: Data on health outcomes and background factors were collected using five standardized annual questionnaires completed by parents at the children's ages of 1-5 y, and their associations with phthalate metabolite urinary concentrations were assessed in 604 mother-son pairs with adjusted multiple logistic regression and Cox's survival model. Several eczema phenotypes were considered. Atopic status was assessed at 5 y of age in 293 boys through total IgE assessment. RESULTS: At 5 y of age, the prevalence of ever eczema was 30.4%. Metabolites of di-isobutyl phthalate (DiBP) and di-isononyl phthalate (DiNP) were positively associated with early-onset (0-24 mo of age) eczema (15.7%) and late-onset (24-60 mo of age) eczema (14.7%). Applying the Cox's model showed a significant association of occurrence of eczema in the first 5 y of life with DiBP and DiNP metabolites. Among IgE-sensitized boys, metabolites of di-n-butyl phthalate (DBP) and DiBP were significantly associated with ever eczema {hazard ratio (HR) = 1.67 [95% confidence interval (CI): 1.10, 2.54], p = 0.01 and HR = 1.87 (95% CI: 1.01, 3.48), p = 0.04, respectively}. CONCLUSIONS: Occurrence of eczema in early childhood may be influenced by prenatal exposure to certain phthalates in boys. Further investigations are needed to confirm this observation. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • Full Text Word Count:
      8900
    • ISSN:
      0091-6765
    • Accession Number:
      10.1289/EHP1829
    • Accession Number:
      128289227
  • Citations
    • ABNT:
      SOOMRO, M. H. et al. Prenatal Exposure to Phthalates and the Development of Eczema Phenotypes in Male Children: Results from the EDEN Mother-Child Cohort Study. Environmental Health Perspectives, [s. l.], v. 126, n. 2, p. 1–9, 2018. DOI 10.1289/EHP1829. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hxh&AN=128289227. Acesso em: 27 jan. 2020.
    • AMA:
      Soomro MH, Baiz N, Philippat C, et al. Prenatal Exposure to Phthalates and the Development of Eczema Phenotypes in Male Children: Results from the EDEN Mother-Child Cohort Study. Environmental Health Perspectives. 2018;126(2):1-9. doi:10.1289/EHP1829.
    • APA:
      Soomro, M. H., Baiz, N., Philippat, C., Vernet, C., Siroux, V., Maesano, C. N., … Annesi-Maesano, I. (2018). Prenatal Exposure to Phthalates and the Development of Eczema Phenotypes in Male Children: Results from the EDEN Mother-Child Cohort Study. Environmental Health Perspectives, 126(2), 1–9. https://doi.org/10.1289/EHP1829
    • Chicago/Turabian: Author-Date:
      Soomro, Munawar Hussain, Nour Baiz, Claire Philippat, Celine Vernet, Valerie Siroux, Cara Nichole Maesano, Shreosi Sanyal, Remy Slama, Carl-Gustaf Bornehag, and Isabella Annesi-Maesano. 2018. “Prenatal Exposure to Phthalates and the Development of Eczema Phenotypes in Male Children: Results from the EDEN Mother-Child Cohort Study.” Environmental Health Perspectives 126 (2): 1–9. doi:10.1289/EHP1829.
    • Harvard:
      Soomro, M. H. et al. (2018) ‘Prenatal Exposure to Phthalates and the Development of Eczema Phenotypes in Male Children: Results from the EDEN Mother-Child Cohort Study’, Environmental Health Perspectives, 126(2), pp. 1–9. doi: 10.1289/EHP1829.
    • Harvard: Australian:
      Soomro, MH, Baiz, N, Philippat, C, Vernet, C, Siroux, V, Maesano, CN, Sanyal, S, Slama, R, Bornehag, C-G & Annesi-Maesano, I 2018, ‘Prenatal Exposure to Phthalates and the Development of Eczema Phenotypes in Male Children: Results from the EDEN Mother-Child Cohort Study’, Environmental Health Perspectives, vol. 126, no. 2, pp. 1–9, viewed 27 January 2020, .
    • MLA:
      Soomro, Munawar Hussain, et al. “Prenatal Exposure to Phthalates and the Development of Eczema Phenotypes in Male Children: Results from the EDEN Mother-Child Cohort Study.” Environmental Health Perspectives, vol. 126, no. 2, Feb. 2018, pp. 1–9. EBSCOhost, doi:10.1289/EHP1829.
    • Chicago/Turabian: Humanities:
      Soomro, Munawar Hussain, Nour Baiz, Claire Philippat, Celine Vernet, Valerie Siroux, Cara Nichole Maesano, Shreosi Sanyal, Remy Slama, Carl-Gustaf Bornehag, and Isabella Annesi-Maesano. “Prenatal Exposure to Phthalates and the Development of Eczema Phenotypes in Male Children: Results from the EDEN Mother-Child Cohort Study.” Environmental Health Perspectives 126, no. 2 (February 2018): 1–9. doi:10.1289/EHP1829.
    • Vancouver/ICMJE:
      Soomro MH, Baiz N, Philippat C, Vernet C, Siroux V, Maesano CN, et al. Prenatal Exposure to Phthalates and the Development of Eczema Phenotypes in Male Children: Results from the EDEN Mother-Child Cohort Study. Environmental Health Perspectives [Internet]. 2018 Feb [cited 2020 Jan 27];126(2):1–9. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=hxh&AN=128289227