The determination of specificity, sensitivity and accuracy of core needle biopsy in the diagnosis of parotid and submandibular salivary glands tumors.

Određivanje specifičnosti, senzitivnosti i tačnosti biopsije šupljom iglom u dijagnostikovanju tumora doušne i podvilične pljuvačne žlezde.

SUBMANDIBULAR gland; CORE needle biopsy; SALIVARY glands; PAROTID glands; MAXILLOFACIAL surgery; PAROTID gland tumors

Background/Aim. The diagnosis of tumors of salivary glands relies heavily on radiological examination and biopsy of pathological tissue. The aim of this study was to investigate the sensitivity, specificity and accuracy of core needle biopsy in diagnosis of tumors of parotid and submandibular glands. Methods. This study was designed as a crosssectional clinical trial performed between May 2008 and May 2015 at the Department of Otorhinolaryngology and Maxillofacial Surgery, Clinical Center Zemun, Belgrade, Serbia. The examinations included 200 patients among which 100 were diagnosed with tumors of parotid salivary glands and 100 with tumors of submandibular salivary glands. The core needle biopsy was undertaken in all cases where tumor was smaller than 2 cm, far from blood vessels and far from the deep layer of parotid gland. The histopathological analysis was performed to identify histological type of the lesion. Upon performing the surgical procedure and consequently the tumor tissue extirpation, tissue samples obtained were investigated for the definitive diagnosis. Results. The sensitivity of the procedure was 90.9% for parotid salivary gland and 74% for submandibular salivary gland, the specificity was 95.9% for parotid salivary gland and 93% for submandibular salivary gland and the accuracy was 94.7% for parotid salivary gland and 87% for submandibular salivary gland. Based on the histopathological findings of the salivary glands obtained using core needle biopsy of the tumor tissue, it was possible to differentiate between malignant and benign lesions. Conclusion. Current investigation points to the advantages and efficiency of core needle biopsy in diagnosis of tumors of parotid and submandibular salivary glands. [ABSTRACT FROM AUTHOR]

Uvod/Cilj. Dijagnoza tumora pljuvačnih žlezda se pretežno zasniva na radiološkom ispitivanju i histološkoj analizi patološke mase dobijene biopsijom. Cilj rada bio je da se ispitaju specifičnost, senzitivnost i tačnost biopsije šupljom iglom u dijagnozi bolesnika sa oboljenjima parotidne i submandibularne pljuvačne žlezde. Metode. Istraživanje je sprovedeno kao studija preseka u Odeljenju za otorinolaringologiju i maksilofacijalnu hirurgiju Kliničkog centra Zemun, Beograd, u periodu od maja 2008. do maja 2016. godine Studijom je bilo obuhvaćeno 200 bolesnika od kojih je kod 100 bio dijagnostikovan tumor u doušnoj pljuvačnoj žlezdi a kod 100 tumor u podviličnoj pljuvačnoj žlezdi. Biopsija šupljom iglom je bila sprovedena kod svih bolesnika kod kojih je tumor bio manji od 2 centimetara, udaljen od krvnih sudova i udaljen od dubokog režnja doušne pljuvačne žlezde. Posle toga je histološkim nalazom utvrđivan tip promene. Posle sprovođenja hirurške intervencije i potpunog uklanjanja obolelog tkiva, uzorak je ispitan za uspostavljanje konačne dijagnoze. Rezultati. Senzitivnost postupka iznosila je 90,9% za doušnu pljuvačnu žlezdu i 74% za podviličnu pljuvačnu žlezdu; specifičnost je bila 95,9% za doušnu pljuvačnu žlezdu; 93% za podviličnu pljuvačnu žlezdu i preciznost je bila 94,7% za doušnu pljuvačnu žlezdu i 87% za podviličnu pljuvačnu žlezdu. Na osnovu histopatološkog nalaza biopsije šupljom iglom bilo je moguće diferencirati maligne od benignih lezija. Zaključak. Sprovedeno istraživanje ukazuje na prednost i efikasnost biopsije šupljom iglom u dijagnozi tumefakata doušne i podvilične pljuvačne žlezde. [ABSTRACT FROM AUTHOR]

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