Profiling prostate biology.

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  • Author(s): Kelly, Kathleen
  • Source:
    Science. 5/1/2020, Vol. 368 Issue 6490, p467-468. 2p. 1 Color Photograph.
  • Additional Information
    • Subject Terms:
    • Abstract:
      The article explores how prostate luminal secretory cells function as facultative stem cells. It discusses molecular profiling of heterogeneous cell populations at the single-cell level using single-cell RNA sequencing has provided refined cell type–specific gene expression signatures. It mentions the requirement for androgen as a cardinal feature in the development and maintenance of normal prostate and for the maintenance of prostate adenocarcinoma.