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Main Library
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Folly Beach Library
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The therapeutic potential of neural stem cells.
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- Author(s): Martino, Gianvito; Pluchino, Stefano
- Source:
Nature Reviews Neuroscience. May2006, Vol. 7 Issue 5, p395-406. 12p. 3 Diagrams, 3 Charts. - Source:
- Additional Information
- Subject Terms:
- Abstract: Recent evidence shows that transplantation of neural stem/precursor cells may protect the central nervous system from inflammatory damage through a 'bystander' mechanism that is alternative to cell replacement. This novel mechanism, which might improve the success of transplantation procedures, is exerted by undifferentiated neural stem cells, the functional characteristics of which are regulated by important stem cell regulators released by CNS-resident and blood-borne inflammatory cells. Here, we discuss this alternative bystander mechanism in the context of the atypical ectopic perivascular niche. We propose that it is the most challenging example of reciprocal therapeutic crosstalk between the inflamed CNS and systemically transplanted neural stem cells. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Nature Reviews Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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