Axonal conduction and injury in multiple sclerosis: the role of sodium channels.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Author(s): Waxman, Stephen G.
  • Source:
    Nature Reviews Neuroscience. Dec2006, Vol. 7 Issue 12, p932-941. 10p. 3 Diagrams, 2 Graphs.
  • Additional Information
    • Subject Terms:
    • Abstract:
      Multiple sclerosis (MS) is the most common cause of neurological disability in young adults. Recent studies have implicated specific sodium channel isoforms as having an important role in several aspects of the pathophysiology of MS, including the restoration of impulse conduction after demyelination, axonal degeneration and the mistuning of Purkinje neurons that leads to cerebellar dysfunction. By manipulating the activity of these channels or their expression, it might be possible to develop new therapeutic approaches that will prevent or limit disability in MS. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Nature Reviews Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)