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effect of A[sub 1] and A[sub 2] receptor antagonists.
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- Author(s): Kopf, Silvia R.; Melani, Alessia; Pedata, Felicita; Pepeu, G.
- Source:
Psychopharmacology. 1999, Vol. 146 Issue 2, p214. 6p. - Source:
- Additional Information
- Subject Terms:
- Abstract: Abstract Rationale: Caffeine is a non-selective A[sub 1]/A[sub 2] adenosine receptor antagonist which is known to improve cognitive performance in humans. This effect of caffeine has been attributed to its antagonism of adenosine receptors. Objective: The present study was devised to identify the role of A[sub l] and A[sub 2A] adenosine receptors in the facilitation of memory consolidation in mice performing a passive avoidance task. Methods: Adult albino Swiss male mice were used. The mice were trained in a step-through inhibitory avoidance task in which they were punished by a foot-shock (0.4 mA, 5 Hz, for 3 s) delivered through the grid floor. Caffeine (0.1, 0.3, 1.0 and 3.0 mg/kg), SCH 58261 (0.1,0.3, 1.0 and 3.0 mg/kg) and DPCPX (0.1, 0.3, 1.0 and 3.0 mg/kg) were injected IP immediately or 180 min after training. The retention test was performed 24 h after training. Results: Caffeine and the selective A[sub 2A] adenosine receptor antagonist SCH 58261 facilitated retention when administered immediately after training, but not when administered 180 min later. The dose response was a bell-shaped curve. Conversely, post-training administration of the selective A[sub 1] adenosine receptor antagonist DPCPX did not affect retention. Caffeine and SCH 58261 had no effect in mice not given the foot-shock on the training trial, a finding indicating that the drug's effect on retention was specific. Conclusions: These results suggest that A[sub 2A] but not A[sub 1] adenosine receptors are involved in memory retention and consolidation. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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