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9 a.m. – 7 p.m.
Phone: (843) 766-6635
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
Folly Beach Library
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John L. Dart Library
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Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans.
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- Author(s): Herndon, Laura A.; Schmeissner, Peter J.; Dudaronek, Justyna M.; Brown, Paula A.; Listner, Kristin M.; Sakano, Yuko; Paupard, Marie C.; Hall, David H.; Driscoll, Monica
- Source:
Nature. 10/24/2002, Vol. 419 Issue 6909, p808. 7p. - Source:
- Additional Information
- Subject Terms:
- Abstract: The nematode Caenorhabditis elegans is an important model for studying the genetics of ageing, with over 50 life-extension mutations known so far. However, little is known about the pathobiology of ageing in this species, limiting attempts to connect genotype with senescent phenotype. Using ultrastructural analysis and visualization of specific cell types with green fluorescent protein, we examined cell integrity in different tissues as the animal ages. We report remarkable preservation of the nervous system, even in advanced old age, in contrast to a gradual, progressive deterioration of muscle, resembling human sarcopenia. The age-1(hx546) mutation, which extends lifespan by 60-100%, delayed some, but not all, cellular biomarkers of ageing. Strikingly, we found strong evidence that stochastic as well as genetic factors are significant in C. elegans ageing, with extensive variability both among same-age animais and between cells of the same type within individuais. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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