Search Results

The deubiquitinase function of ataxin-3 and its role in the pathogenesis of Machado-Joseph disease and other diseases.

• Authors : Potapenko, Anastasiya; Davidson, Jennilee M.; Lee, Albert

Subjects: REGULATOR genes; LIFE expectancy; PATHOGENESIS

• Source: Biochemical Journal; Mar2024, Vol. 481 Issue 6, p461-480, 20p

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Ataxin-3, The Spinocerebellar Ataxia Type 3 Neurodegenerative Disorder Protein, Affects Mast Cell Functions.

• Authors : Sowa, Anna S.; Haas, Eva; Hübener-Schmid, Jeannette

Subjects: MAST cells; SPINOCEREBELLAR ataxia; CELL physiology

• Source: Frontiers in Immunology; 4/26/2022, Vol. 13, p1-10, 10p

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Autophagy Function and Benefits of Autophagy Induction in Models of Spinocerebellar Ataxia Type 3.

• Authors : Watchon, Maxinne; Luu, Luan; Plenderleith, Stuart K.

Subjects: HUNTINGTIN protein; SPINOCEREBELLAR ataxia; AUTOPHAGY

• Source: Cells (2073-4409); Mar2023, Vol. 12 Issue 6, p893, 16p

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Spermidine treatment: induction of autophagy but also apoptosis?

• Authors : Watchon, Maxinne; Wright, Amanda L.; Ahel, Holly I.

Subjects: SPERMIDINE; AUTOPHAGY; TRINUCLEOTIDE repeats

• Source: Molecular Brain; 3/5/2024, Vol. 17 Issue 1, p1-15, 15p

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Autophagy-independent cytoprotection by optineurin from toxicity of aggregates formed by mutant huntingtin and mutant ataxin-3.

• Authors : Moharir, Shivranjani C; Raghawan, Akhouri Kishore; Ramaswamy, Rajashree

Subjects: MUTANT proteins; CONFOCAL microscopy; POISONS

• Source: Journal of Biochemistry; May2022, Vol. 171 Issue 5, p555-565, 11p

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p45, an ATPase subunit of the 19S proteasome, targets the polyglutamine disease protein ataxin-3 to the proteasome.

• Authors : Hongfeng Wang; Nali Jia; Erkang Fei

Subjects: NEURODEGENERATION; ADENOSINE triphosphatase; GLUTAMINE

• Source: Journal of Neurochemistry; Jun2007, Vol. 101 Issue 6, p1651-1661, 11p, 4 Black and White Photographs, 4 Diagrams

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Ubiquitin-binding site 1 of pathogenic ataxin-3 regulates its toxicity in Drosophila models of Spinocerebellar Ataxia Type 3

• Authors : Prifti, Matthew V.; Libohova, Kozeta; Harris, Autumn L.

• Source: Frontiers in Neuroscience; 1/17/2023, Vol. 16, p1-13, 13p, 1 Color Photograph, 5 Graphs

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Altered Expression of Carbonic Anhydrase-Related Protein XI in Neuronal Cells Expressing Mutant Ataxin-3.

• Authors : Hsieh, Mingli; Chang, Wei-Hsiu; Hsu, Chi-Fu

Subjects: GENE expression; CARBONIC anhydrase; NEURONS

• Source: Cerebellum; Jun2013, Vol. 12 Issue 3, p338-349, 12p

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Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado–Joseph disease.

• Authors : Nascimento-Ferreira, Isabel; Santos-Ferreira, Tiago; Sousa-Ferreira, Lígia

Subjects: ATAXIA; GENE expression; AUTOPHAGY

• Source: Brain: A Journal of Neurology; May2011, Vol. 134 Issue 5, p1400-1415, 16p

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Sodium valproate increases activity of the sirtuin pathway resulting in beneficial effects for spinocerebellar ataxia-3 in vivo.

• Authors : Watchon, Maxinne; Luu, Luan; Robinson, Katherine J.

Subjects: VALPROIC acid; RESVERATROL; SIRTUINS

• Source: Molecular Brain; 8/20/2021, Vol. 14 Issue 1, p1-16, 16p

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