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Academic Journal

Vulnerability of frontal brain neurons for the toxicity of expanded ataxin-3.

  • Authors : Schmidt J; SCA3 research group, Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen, Germany.; Center for Rare Diseases, University of Tuebingen, Tuebingen, Germany.

Subjects: Trinucleotide Repeat Expansion*; Ataxin-3/Ataxin-3/Ataxin-3/*genetics ; Frontal Lobe/Frontal Lobe/Frontal Lobe/*metabolism

  • Source: Human molecular genetics [Hum Mol Genet] 2019 May 01; Vol. 28 (9), pp. 1463-1473.Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3.

  • Authors : Chen ZS; Laboratory of Drosophila Research, School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR, China.; Nexus of Rare Neurodegenerative Diseases, School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR, China.

Subjects: Ataxin-3/Ataxin-3/Ataxin-3/*metabolism ; DNA Repair Enzymes/DNA Repair Enzymes/DNA Repair Enzymes/*metabolism ; Drosophila Proteins/Drosophila Proteins/Drosophila Proteins/*metabolism

  • Source: Cell death & disease [Cell Death Dis] 2021 Feb 02; Vol. 12 (2), pp. 136. Date of Electronic Publication: 2021 Feb 02.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

The Role of MicroRNAs in Spinocerebellar Ataxia Type 3.

  • Authors : Krauss S; German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Street 27, 53127 Bonn, Germany.; Evert BO

Subjects: Ataxin-3/Ataxin-3/Ataxin-3/*genetics ; Brain/Brain/Brain/*metabolism ; Machado-Joseph Disease/Machado-Joseph Disease/Machado-Joseph Disease/*genetics

  • Source: Journal of molecular biology [J Mol Biol] 2019 Apr 19; Vol. 431 (9), pp. 1729-1742. Date of Electronic Publication: 2019 Jan 18.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Coiled-coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects.

  • Authors : Kwon MJ; Department of Brain & Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology, 42988 Daegu, Republic of Korea.; Han MH

Subjects: Ataxin-3/Ataxin-3/Ataxin-3/*chemistry ; Drosophila Proteins/Drosophila Proteins/Drosophila Proteins/*chemistry ; Drosophila melanogaster/Drosophila melanogaster/Drosophila melanogaster/*genetics

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Nov 06; Vol. 115 (45), pp. E10748-E10757. Date of Electronic Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models.

  • Authors : Matos CA; CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra, 3004-517 Coimbra, Portugal.; Nóbrega C

Subjects: Nerve Degeneration*; Ataxin-3/Ataxin-3/Ataxin-3/*metabolism ; Cerebral Cortex/Cerebral Cortex/Cerebral Cortex/*enzymology

  • Source: The Journal of cell biology [J Cell Biol] 2016 Feb 15; Vol. 212 (4), pp. 465-80.Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 0375356 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Druggable genome screen identifies new regulators of the abundance and toxicity of ATXN3, the Spinocerebellar Ataxia type 3 disease protein.

  • Authors : Ashraf NS; Department of Neurology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.; Sutton JR

Subjects: Ataxin-3/Ataxin-3/Ataxin-3/*genetics ; Machado-Joseph Disease/Machado-Joseph Disease/Machado-Joseph Disease/*genetics ; Neurons/Neurons/Neurons/*metabolism

  • Source: Neurobiology of disease [Neurobiol Dis] 2020 Apr; Vol. 137, pp. 104697. Date of Electronic Publication: 2019 Nov 26.Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease.

  • Authors : Teixeira-Castro A; 1 Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal 2 ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimarães, Portugal 3 Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, USA 4 Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208, USA.; Jalles A

Subjects: Ataxin-3/Ataxin-3/Ataxin-3/*drug effects ; Caenorhabditis elegans Proteins/Caenorhabditis elegans Proteins/Caenorhabditis elegans Proteins/*drug effects ; Citalopram/Citalopram/Citalopram/*pharmacology

  • Source: Brain : a journal of neurology [Brain] 2015 Nov; Vol. 138 (Pt 11), pp. 3221-37. Date of Electronic Publication: 2015 Sep 15.Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Caffeic acid and resveratrol ameliorate cellular damage in cell and Drosophila models of spinocerebellar ataxia type 3 through upregulation of Nrf2 pathway.

  • Authors : Wu YL; Department of Nutrition, Chung Shan Medical University, No. 110, Sec. 1, Chien-Kuo N. Rd., Taichung 40203, Taiwan, ROC.; Chang JC

Subjects: Ataxin-3/Ataxin-3/Ataxin-3/*genetics ; Caffeic Acids/Caffeic Acids/Caffeic Acids/*therapeutic use ; Machado-Joseph Disease/Machado-Joseph Disease/Machado-Joseph Disease/*drug therapy

  • Source: Free radical biology & medicine [Free Radic Biol Med] 2018 Feb 01; Vol. 115, pp. 309-317. Date of Electronic Publication: 2017 Dec 13.Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

A novel nuclear DnaJ protein, DNAJC8, can suppress the formation of spinocerebellar ataxia 3 polyglutamine aggregation in a J-domain independent manner.

  • Authors : Ito N; Department of Pathology, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-ku, Sapporo 060-8556, Japan; Department of Neurology, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-ku, Sapporo 060-8556, Japan.

Subjects: Ataxin-3/Ataxin-3/Ataxin-3/*metabolism ; HSP40 Heat-Shock Proteins/HSP40 Heat-Shock Proteins/HSP40 Heat-Shock Proteins/*metabolism ; Machado-Joseph Disease/Machado-Joseph Disease/Machado-Joseph Disease/*metabolism

  • Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2016 Jun 10; Vol. 474 (4), pp. 626-633. Date of Electronic Publication: 2016 Apr 28.Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  203 results for ""Ataxin-3""