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Cryo-EM structures of anti-malarial antibody L9 with circumsporozoite protein reveal trimeric L9 association and complete 27-residue epitope.

• Authors : Tripathi P; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.; Bender MF

Subjects: Antimalarials* ; Malaria Vaccines* ; Malaria*

• Source: Structure (London, England : 1993) [Structure] 2023 Apr 06; Vol. 31 (4), pp. 480-491.e4. Date of Electronic Publication: 2023 Mar 16.Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies.

• Authors : Kratochvil S; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Shen CH

Subjects: B-Lymphocyte Subsets/B-Lymphocyte Subsets/B-Lymphocyte Subsets/*immunology ; Epitopes/Epitopes/Epitopes/*immunology ; Malaria/Malaria/Malaria/*immunology

• Source: Immunity [Immunity] 2021 Dec 14; Vol. 54 (12), pp. 2859-2876.e7. Date of Electronic Publication: 2021 Nov 16.Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Protective effects of combining monoclonal antibodies and vaccines against the Plasmodium falciparum circumsporozoite protein.

• Authors : Wang, Lawrence T.; Pereira, Lais S.; Kiyuka, Patience K.

Subjects: CIRCUMSPOROZOITE protein; PLASMODIUM falciparum; MALARIA

• Source: PLoS Pathogens; 12/6/2021, Vol. 17 Issue 12, p1-26, 26p

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Aedes aegypti SGS1 is critical for Plasmodium gallinaceum infection of both the mosquito midgut and salivary glands.

• Authors : Kojin, Bianca B.; Martin-Martin, Ines; Araújo, Helena R. C.

Subjects: AEDES aegypti; SALIVARY glands; SALIVARY proteins

• Source: Malaria Journal; 1/6/2021, Vol. 20 Issue 1, p1-15, 15p

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The light chain of the L9 antibody is critical for binding circumsporozoite protein minor repeats and preventing malaria.

• Authors : Wang, Lawrence T.; Hurlburt, Nicholas K.; Schön, Arne

• Source: Cell Reports; Feb2022, Vol. 38 Issue 7, pN.PAG-N.PAG, 1p

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