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Academic Journal

Retromer-dependent lysosomal stress in Parkinson's disease.

Subjects: PARKINSON'S disease; GENETIC mutation; DARDARIN

  • Source: Philosophical Transactions of the Royal Society B: Biological Sciences; 4/8/2024, Vol. 379 Issue 1899, p1-5, 5p

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Academic Journal

LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression.

Subjects: DARDARIN; NEUROFIBRILLARY tangles; CHRONIC traumatic encephalopathy

  • Source: Translational Neurodegeneration; 3/4/2024, Vol. 13 Issue 1, p1-20, 20p

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Academic Journal

Leucine‐rich repeat kinase 2 (LRRK2) inhibition upregulates microtubule‐associated protein 1B to ameliorate lysosomal dysfunction and parkinsonism.

Subjects: DARDARIN; MICROTUBULE-associated proteins; PARKINSON'S disease

  • Source: MedComm; Dec2023, Vol. 4 Issue 6, p1-16, 16p

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Academic Journal

A leucine‐rich repeat kinase 2 (LRRK2) pathway biomarker characterization study in patients with Parkinson's disease with and without LRRK2 mutations and healthy controls.

Subjects: DARDARIN; CEREBROSPINAL fluid examination; PARKINSON'S disease

  • Source: CTS: Clinical & Translational Science; Aug2023, Vol. 16 Issue 8, p1408-1420, 13p

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Academic Journal

Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity.

Subjects: DARDARIN; KINASES; GENETIC transformation

  • Source: Journal of Parkinson's Disease; 2022, Vol. 12 Issue 5, p1423-1447, 25p

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Academic Journal

A LRRK2/dLRRK‐mediated lysosomal pathway that contributes to glial cell death and DA neuron survival.

Subjects: LYSOSOMES; NEUROGLIA; DARDARIN

  • Source: Traffic; Oct2022, Vol. 23 Issue 10, p506-520, 15p

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Academic Journal

α-Synuclein-containing erythrocytic extracellular vesicles: essential contributors to hyperactivation of monocytes in Parkinson's disease.

Subjects: PARKINSON'S disease; DARDARIN; EXTRACELLULAR vesicles

  • Source: Journal of Neuroinflammation; 2/22/2022, Vol. 19 Issue 1, p1-19, 19p

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Academic Journal

LRRK2 mutant knock-in mouse models: therapeutic relevance in Parkinson's disease.

Subjects: PARKINSON'S disease; DARDARIN; LABORATORY mice

  • Source: Translational Neurodegeneration; 2/14/2022, Vol. 11 Issue 1, p1-19, 19p

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Academic Journal

LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson's disease.

Subjects: DARDARIN; PROTEIN kinases; PARKINSON'S disease

  • Source: Translational Neurodegeneration; 1/31/2022, Vol. 11 Issue 1, p1-14, 14p

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Academic Journal

Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.

Subjects: MICROGLIA; TRANSFERRIN; LYSOSOMES

  • Source: PLoS Biology; 12/16/2021, Vol. 19 Issue 12, p1-30, 30p, 2 Charts, 7 Graphs

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  • 1-10 of  19 results for ""De Miranda BR""