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Academic Journal

Oxidative activation of the thiophene ring by hepatic enzymes. Hydroxylation and formation of electrophilic metabolites during metabolism of tienilic acid and its isomer by rat liver microsomes.

  • Authors : Dansette PM; Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Université René Descartes, Paris, France.; Amar C

Subjects: Glycolates/Glycolates/Glycolates/*metabolism ; Microsomes, Liver/Microsomes, Liver/Microsomes, Liver/*enzymology ; NADP/NADP/NADP/*metabolism

  • Source: Biochemical pharmacology [Biochem Pharmacol] 1990 Mar 01; Vol. 39 (5), pp. 911-8.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print Cited Medium: Print ISSN: 0006-2952 (Print)

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Academic Journal

A dissolution anomaly involving ticrynafen in simulated intestinal fluid without enzyme.

Subjects: Glycolates* ; Potassium* ; Ticrynafen*

  • Source: Journal of pharmaceutical sciences [J Pharm Sci] 1982 Apr; Vol. 71 (4), pp. 406-9.Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print Cited Medium: Print ISSN: 0022-3549 (Print)

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Academic Journal

Metabolic hydroxylation of the thiophene ring: isolation of 5-hydroxy-tienilic acid as the major urinary metabolite of tienilic acid in man and rat.

Subjects: Glycolates/Glycolates/Glycolates/*metabolism ; Glycolates/Glycolates/Glycolates/*urine ; Ticrynafen/Ticrynafen/Ticrynafen/*metabolism

  • Source: Biochemical pharmacology [Biochem Pharmacol] 1984 May 01; Vol. 33 (9), pp. 1429-35.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print Cited Medium: Print ISSN: 0006-2952 (Print)

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Report

[Acute thrombopenic purpura after ingestion of tienilic acid].

Subjects: Glycolates/Glycolates/Glycolates/*adverse effects ; Purpura, Thrombocytopenic/Purpura, Thrombocytopenic/Purpura, Thrombocytopenic/*chemically induced ; Ticrynafen/Ticrynafen/Ticrynafen/*adverse effects

  • Source: La Nouvelle presse medicale [Nouv Presse Med] 1982 Jun 19; Vol. 11 (29), pp. 2226-7.Publisher: Masson Country of Publication: France NLM ID: 0312552 Publication Model: Print Cited Medium: Print ISSN: 0301-1518 (Print) Linking

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Academic Journal

Effect of tienilic acid and amiloride in healthy volunteers and in hypertensives with normal renal function.

Subjects: Amiloride/Amiloride/Amiloride/*pharmacology ; Glycolates/Glycolates/Glycolates/*pharmacology ; Hypertension/Hypertension/Hypertension/*drug therapy

  • Source: British journal of clinical pharmacology [Br J Clin Pharmacol] 1980 Oct; Vol. 10 (4), pp. 345-51.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print Cited Medium: Print ISSN: 0306-5251 (Print)

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Academic Journal

A new anti-liver-kidney microsome antibody (anti-LKM2) in tienilic acid-induced hepatitis.

Subjects: Autoantibodies/Autoantibodies/Autoantibodies/*analysis ; Chemical and Drug Induced Liver Injury/Chemical and Drug Induced Liver Injury/Chemical and Drug Induced Liver Injury/*immunology ; Glycolates/Glycolates/Glycolates/*adverse effects

  • Source: Clinical and experimental immunology [Clin Exp Immunol] 1984 Mar; Vol. 55 (3), pp. 561-70.Publisher: Oxford University Press Country of Publication: England NLM ID: 0057202 Publication Model: Print Cited Medium: Print ISSN: 0009-9104

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Academic Journal

[Tienilic acid can induce acute hepatitis, chronic hepatitis and cirrhosis. A report of three cases (author's transl)].

Subjects: Chemical and Drug Induced Liver Injury/Chemical and Drug Induced Liver Injury/Chemical and Drug Induced Liver Injury/*etiology ; Glycolates/Glycolates/Glycolates/*adverse effects ; Liver Cirrhosis/Liver Cirrhosis/Liver Cirrhosis/*chemically induced

  • Source: Gastroenterologie clinique et biologique [Gastroenterol Clin Biol] 1981 May; Vol. 5 (5), pp. 567-71.Publisher: Elsevier Masson Country of Publication: France NLM ID: 7704825 Publication Model: Print Cited Medium: Print ISSN: 0399-8320 (Print)

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Academic Journal

Uricosuric effect of tienilic acid in normo- and hyperuricaemic hypertensive patients.

Subjects: Glycolates/Glycolates/Glycolates/*therapeutic use ; Hypertension/Hypertension/Hypertension/*drug therapy ; Ticrynafen/Ticrynafen/Ticrynafen/*therapeutic use

  • Source: Postgraduate medical journal [Postgrad Med J] 1979; Vol. 55 Suppl 3, pp. 68-74.Publisher: Oxford University Press Country of Publication: England NLM ID: 0234135 Publication Model: Print Cited Medium: Print ISSN: 0032-5473

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Academic Journal

Tienilic acid: a single treatment for hyperuricaemia and hypertension?

Subjects: Glycolates/Glycolates/Glycolates/*therapeutic use ; Hypertension/Hypertension/Hypertension/*drug therapy ; Ticrynafen/Ticrynafen/Ticrynafen/*therapeutic use

  • Source: Annals of the rheumatic diseases [Ann Rheum Dis] 1980 Aug; Vol. 39 (4), pp. 373-6.Publisher: BMJ Country of Publication: England NLM ID: 0372355 Publication Model: Print Cited Medium: Print ISSN: 0003-4967 (Print) Linking

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Academic Journal

One year follow-up of hyperuricaemic hypertensive patients treated with tienilic acid or a diuretic with or without uric acid-lowering drugs.

Subjects: Amiloride/Amiloride/Amiloride/*therapeutic use ; Cyclopenthiazide/Cyclopenthiazide/Cyclopenthiazide/*therapeutic use ; Glycolates/Glycolates/Glycolates/*therapeutic use

  • Source: Clinical science (London, England : 1979) [Clin Sci (Lond)] 1979 Dec; Vol. 57 Suppl 5, pp. 379s-382s.Publisher: Portland Press on behalf of the Medical Research Society and the Biochemical Society Country of Publication: England NLM ID: 7905731 Publication Model:

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  • 1-10 of  130 results for ""Glycolates""