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Academic Journal

Structure of a presenilin family intramembrane aspartate protease.

Authors : Li, Xiaochun; Dang, Shangyu; Yan, Chuangye

Subjects: PRESENILINS; PEPTIDASE; ASPARTATES

Source: Nature. 1/3/2013, Vol. 493 Issue 7430, p56-61. 6p. 4 Diagrams.

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Academic Journal

Presenilins are essential for regulating neurotransmitter release.

Authors : Chen Zhang; Bei Wu; Beglopoulos, Vassilios

Subjects: PRESENILINS; ALZHEIMER'S disease; NEURAL transmission

Source: Nature. 7/30/2009, Vol. 460 Issue 7255, p632-636. 5p. 4 Graphs.

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Academic Journal

TMP21 is a presenilin complex component that modulates γ-secretase but not ɛ-secretase activity.

Authors : Fusheng Chen; Hasegawa, Hiroshi; Schmitt-Ulms, Gerold

Subjects: PRESENILINS; MEMBRANE proteins; CADHERINS

Source: Nature. 4/27/2006, Vol. 440 Issue 7088, p1208-1212. 5p. 4 Diagrams.

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Academic Journal

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.

Authors : Li, Yue-Ming; Xu, Min; Lai, Ming-Tain

Subjects: PRESENILINS; ALZHEIMER'S disease; PHOTOAFFINITY labeling

Source: Nature. 6/8/2000, Vol. 405 Issue 6787, p689. 6p. 6 Diagrams, 6 Charts, 2 Graphs.

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Academic Journal

Destabilization of beta catenin by mutations in presenilin-1 potentiates neuronal apoptosis.

Authors : Zhang, Zhuohua; Hartmann, Henrike; Viet Minh Do

Subjects: PRESENILINS; GENETICS of Alzheimer's disease; MEMBRANE proteins

Source: Nature. 10/15/1998, Vol. 395 Issue 6703, p698. 5p. 6 Color Photographs, 9 Black and White Photographs, 4 Graphs.

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Academic Journal

Structural biology: Membrane enzyme cuts a fine figure.

Authors : Wolfe, Michael S.

Subjects: PRESENILINS; ALZHEIMER'S disease; MEMBRANE proteins

Source: Nature. 1/3/2013, Vol. 493 Issue 7430, p34-35. 2p. 1 Diagram.

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Academic Journal

Neurobiology: Double trouble for neurons.

Authors : Fortini, Mark E.

Subjects: ALZHEIMER'S disease; GENETIC mutation; PRESENILINS

Source: Nature. 10/9/2003, Vol. 425 Issue 6958, p565. 2p.

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