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Academic Journal

Buffering of transcription rate by mRNA half-life is a conserved feature of Rett syndrome models.

  • Authors : Rodrigues DC; Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.; Mufteev M

Subjects: Rett Syndrome*/Rett Syndrome*/Rett Syndrome*/genetics; Humans ; Mice

  • Source: Nature communications [Nat Commun] 2023 Apr 05; Vol. 14 (1), pp. 1896. Date of Electronic Publication: 2023 Apr 05.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Transcriptional buffering and 3'UTR lengthening are shaped during human neurodevelopment by shifts in mRNA stability and microRNA load.

  • Authors : Mufteev M; Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

  • Source: BioRxiv : the preprint server for biology [bioRxiv] 2023 Mar 01. Date of Electronic Publication: 2023 Mar 01.Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not

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Academic Journal

Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome.

  • Authors : Rodrigues DC; Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Mufteev M

Subjects: Ubiquitination*/Ubiquitination*/Ubiquitination*/genetics; Nervous System/Nervous System/Nervous System/*growth & development ; Nervous System/Nervous System/Nervous System/*pathology

  • Source: Cell reports [Cell Rep] 2020 Mar 24; Vol. 30 (12), pp. 4179-4196.e11.Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247

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Academic Journal

Synaptic Dysfunction in Human Neurons With Autism-Associated Deletions in PTCHD1-AS.

  • Authors : Ross PJ; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Zhang WB

Subjects: Autism Spectrum Disorder*/Autism Spectrum Disorder*/Autism Spectrum Disorder*/genetics ; Autistic Disorder*/Autistic Disorder*/Autistic Disorder*/genetics ; Induced Pluripotent Stem Cells*

  • Source: Biological psychiatry [Biol Psychiatry] 2020 Jan 15; Vol. 87 (2), pp. 139-149. Date of Electronic Publication: 2019 Jul 29.Publisher: Elsevier Country of Publication: United States NLM ID: 0213264 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Precision Health Resource of Control iPSC Lines for Versatile Multilineage Differentiation.

  • Authors : Hildebrandt MR; Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Reuter MS

Subjects: Cell Differentiation* ; Cell Lineage*; Induced Pluripotent Stem Cells/Induced Pluripotent Stem Cells/Induced Pluripotent Stem Cells/*cytology

  • Source: Stem cell reports [Stem Cell Reports] 2019 Dec 10; Vol. 13 (6), pp. 1126-1141.Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print Cited Medium: Internet ISSN: 2213-6711

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Academic Journal

SHANK2 mutations associated with autism spectrum disorder cause hyperconnectivity of human neurons.

  • Authors : Zaslavsky K; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Molecular Genetics, The University of Toronto, Toronto, Ontario, Canada.

Subjects: Autism Spectrum Disorder/Autism Spectrum Disorder/Autism Spectrum Disorder/*genetics ; Autism Spectrum Disorder/Autism Spectrum Disorder/Autism Spectrum Disorder/*pathology ; Dendrites/Dendrites/Dendrites/*pathology

  • Source: Nature neuroscience [Nat Neurosci] 2019 Apr; Vol. 22 (4), pp. 556-564. Date of Electronic Publication: 2019 Mar 25.Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

CNTN5 - /+ or EHMT2 - /+ human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks.

  • Authors : Deneault E; Genetics & Genome Biology Program, The Hospital for Sick Children, Toronto, Canada.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Canada.

Subjects: Autistic Disorder/Autistic Disorder/Autistic Disorder/*physiopathology ; Contactins/Contactins/Contactins/*metabolism ; Histocompatibility Antigens/Histocompatibility Antigens/Histocompatibility Antigens/*metabolism

  • Source: ELife [Elife] 2019 Feb 12; Vol. 8. Date of Electronic Publication: 2019 Feb 12.Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet

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Complete Disruption of Autism-Susceptibility Genes by Gene Editing Predominantly Reduces Functional Connectivity of Isogenic Human Neurons.

  • Source: Stem cell reports [Stem Cell Reports] 2019 Feb 12; Vol. 12 (2), pp. 427-429.Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print Cited Medium: Internet ISSN: 2213-6711

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Academic Journal

Complete Disruption of Autism-Susceptibility Genes by Gene Editing Predominantly Reduces Functional Connectivity of Isogenic Human Neurons.

  • Authors : Deneault E; Genetics & Genome Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.

Subjects: Gene Editing* ; Genetic Predisposition to Disease*; Autistic Disorder/Autistic Disorder/Autistic Disorder/*genetics

  • Source: Stem cell reports [Stem Cell Reports] 2018 Nov 13; Vol. 11 (5), pp. 1211-1225. Date of Electronic Publication: 2018 Nov 01.Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The Personal Genome Project Canada: findings from whole genome sequences of the inaugural 56 participants.

  • Authors : Reuter MS; The Centre for Applied Genomics (Reuter, Walker, Thiruvahindrapuram, Whitney, Yuen, Trost, Paton, Pereira, Herbrick, Wintle, Merico, Howe, MacDonald, Lu, Nalpathamkalam, Sung, Wang, Patel, Pellecchia, J. Wei, Strug, Bell, Kellam, Mahtani, Hosseini, Fiume, Marshall, Buchanan, Scherer); Divisions of Clinical Pharmacology and Toxicology (I. Cohn), or Clinical, and Metabolic Genetics (Sondheimer, Weksberg, Shuman, Bowdin, Meyn, Monfared), The Hospital for Sick Children

Subjects: Genetic Variation/Genetic Variation/Genetic Variation/*genetics ; Genome, Human/Genome, Human/Genome, Human/*genetics ; Sequence Analysis, DNA/Sequence Analysis, DNA/Sequence Analysis, DNA/*methods

  • Source: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne [CMAJ] 2018 Feb 05; Vol. 190 (5), pp. E126-E136.Publisher: Canadian Medical Association Country of Publication: Canada NLM ID: 9711805 Publication Model: Print Cited Medium: Internet ISSN:

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