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Academic Journal

14-3-3 interaction with phosphodiesterase 8A sustains PKA signaling and downregulates the MAPK pathway.

  • Authors : Mukherjee S; Department of Biological Sciences, Bose Institute, Kolkata, India.; Roy S

Subjects: 14-3-3 Proteins*/14-3-3 Proteins*/14-3-3 Proteins*/metabolism ; 3',5'-Cyclic-AMP Phosphodiesterases*/3',5'-Cyclic-AMP Phosphodiesterases*/3',5'-Cyclic-AMP Phosphodiesterases*/metabolism ; Cyclic AMP-Dependent Protein Kinases*/Cyclic AMP-Dependent Protein Kinases*/Cyclic AMP-Dependent Protein Kinases*/metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2024 Mar; Vol. 300 (3), pp. 105725. Date of Electronic Publication: 2024 Feb 06.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Knockout of M-LP/Mpv17L, a newly identified atypical PDE, induces physiological afferent cardiac hypertrophy in mice.

  • Authors : Iida R; Molecular Neuroscience Unit, School of Medical Sciences, University of Fukui, Fukui, 910-1193, Japan. .; Ueki M

Subjects: Cardiomegaly*/Cardiomegaly*/Cardiomegaly*/genetics ; Cardiomegaly*/Cardiomegaly*/Cardiomegaly*/metabolism ; 3',5'-Cyclic-AMP Phosphodiesterases*/3',5'-Cyclic-AMP Phosphodiesterases*/3',5'-Cyclic-AMP Phosphodiesterases*/genetics

  • Source: Transgenic research [Transgenic Res] 2023 Dec; Vol. 32 (6), pp. 575-582. Date of Electronic Publication: 2023 Oct 18.Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 9209120 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

An overview of phosphodiesterase 9 inhibitors: Insights from skeletal structure, pharmacophores, and therapeutic potential.

  • Authors : Zheng L; Innovation Program of Drug Research on Neurological and Metabolic Diseases, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.; Zhou ZZ

Subjects: 3',5'-Cyclic-AMP Phosphodiesterases* ; Phosphodiesterase Inhibitors*/Phosphodiesterase Inhibitors*/Phosphodiesterase Inhibitors*/pharmacology ; Phosphodiesterase Inhibitors*/Phosphodiesterase Inhibitors*/Phosphodiesterase Inhibitors*/therapeutic use

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2023 Nov 05; Vol. 259, pp. 115682. Date of Electronic Publication: 2023 Jul 28.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

cAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor.

  • Authors : Campolo F; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.; Capponi C

Subjects: 3',5'-Cyclic-AMP Phosphodiesterases*/3',5'-Cyclic-AMP Phosphodiesterases*/3',5'-Cyclic-AMP Phosphodiesterases*/genetics ; 3',5'-Cyclic-AMP Phosphodiesterases*/3',5'-Cyclic-AMP Phosphodiesterases*/3',5'-Cyclic-AMP Phosphodiesterases*/metabolism ; Leydig Cell Tumor*/Leydig Cell Tumor*/Leydig Cell Tumor*/genetics

  • Source: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2022 Oct 07; Vol. 13, pp. 1010924. Date of Electronic Publication: 2022 Oct 07 (Print Publication: 2022).Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print

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Academic Journal

Homology Modeling and Molecular Dynamics Simulations of Trypanosoma cruzi Phosphodiesterase b1.

  • Authors : Llanos MA; Laboratory of Bioactive Research and Development (LIDeB), Faculty of Exact Sciences, University of La Plata - 47 and 115, La Plata, Buenos Aires, Argentina.; Alberca LN

Subjects: 3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/*chemistry ; Protozoan Proteins/Protozoan Proteins/Protozoan Proteins/*chemistry ; Small Molecule Libraries/Small Molecule Libraries/Small Molecule Libraries/*chemistry

  • Source: Chemistry & biodiversity [Chem Biodivers] 2022 Jan; Vol. 19 (1), pp. e202100712. Date of Electronic Publication: 2021 Dec 16.Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Phosphodiesterase 8A Regulates CFTR Activity in Airway Epithelial Cells.

  • Authors : Turner MJ; Department of Physiology, McGill University, Montréal, QC, Canada, .; Cystic Fibrosis Translational Research Centre, McGill University, Montréal, QC, Canada.

Subjects: 3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/*metabolism ; Cystic Fibrosis/Cystic Fibrosis/Cystic Fibrosis/*metabolism ; Cystic Fibrosis Transmembrane Conductance Regulator/Cystic Fibrosis Transmembrane Conductance Regulator/Cystic Fibrosis Transmembrane Conductance Regulator/*metabolism

  • Source: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology [Cell Physiol Biochem] 2021 Dec 23; Vol. 55 (6), pp. Publisher: Cell Physiol Biochem Press GmbH & Co KG Country of Publication: Germany NLM ID: 9113221 Publication Model: Print Cited Medium: Internet

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Academic Journal

High Expression of PDE8B and DUOX2 Associated with Ability of Metastasis in Thyroid Carcinoma.

  • Authors : Sun Z; Department of Nuclear Medicine, The First People's Hospital of Lianyungang, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang City 222000, China.; Yuan X

Subjects: 3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/*genetics ; Dual Oxidases/Dual Oxidases/Dual Oxidases/*genetics ; Thyroid Neoplasms/Thyroid Neoplasms/Thyroid Neoplasms/*genetics

  • Source: Computational and mathematical methods in medicine [Comput Math Methods Med] 2021 Dec 20; Vol. 2021, pp. 2362195. Date of Electronic Publication: 2021 Dec 20 (Print Publication:Publisher: Hindawi Country of Publication: United States NLM ID: 101277751 Publication Model: eCollection Cited Medium: Internet ISSN: 1748-6718

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Academic Journal

Inhibition of phosphodiesterase type 9 reduces obesity and cardiometabolic syndrome in mice.

Subjects: 3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/*metabolism ; Adipose Tissue/Adipose Tissue/Adipose Tissue/*embryology ; Metabolic Syndrome/Metabolic Syndrome/Metabolic Syndrome/*enzymology

  • Source: The Journal of clinical investigation [J Clin Invest] 2021 Nov 01; Vol. 131 (21).Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print Cited Medium:

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Academic Journal

Gastrodin promotes hippocampal neurogenesis via PDE9-cGMP-PKG pathway in mice following cerebral ischemia.

  • Authors : Xiao H; Department of Pharmacology, College of Pharmacy, Chongqing Key Lab of Biochemistry and Molecular Pharmacology, Chongqing Key Laboratory of Drug Metabolism, Chongqing Medical University, Chongqing, China; Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, China.

Subjects: 3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/*metabolism ; Benzyl Alcohols/Benzyl Alcohols/Benzyl Alcohols/*pharmacology ; Brain Ischemia/Brain Ischemia/Brain Ischemia/*metabolism

  • Source: Neurochemistry international [Neurochem Int] 2021 Nov; Vol. 150, pp. 105171. Date of Electronic Publication: 2021 Aug 19.Publisher: Pergamon Press Country of Publication: England NLM ID: 8006959 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

PDE9A deficiency does not prevent chronic-hypoxic pulmonary hypertension in mice.

  • Authors : Kolb TM; Division of Pulmonary and Critical Care Medicine Pulmonary, Johns Hopkins University, Baltimore, Maryland, USA.; Johnston L

Subjects: 3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/3',5'-Cyclic-AMP Phosphodiesterases/*metabolism ; Hypertension, Pulmonary/Hypertension, Pulmonary/Hypertension, Pulmonary/*metabolism ; Hypoxia/Hypoxia/Hypoxia/*metabolism

  • Source: Physiological reports [Physiol Rep] 2021 Sep; Vol. 9 (18), pp. e15057.Publisher: published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society Country of Publication: United States NLM

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  • 1-10 of  5,432 results for ""3',5'-Cyclic-AMP Phosphodiesterases""