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Academic Journal

Molecular Insights into the Impact of Mutations on the Binding Affinity of Targeted Covalent Inhibitors of BTK.

Subjects: Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/antagonists & inhibitors ; Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/genetics; Molecular Conformation

  • Source: The journal of physical chemistry. B [J Phys Chem B] 2024 Mar 28; Vol. 128 (12), pp. 2874-2884. Date of Electronic Publication: 2024 Mar 19.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101157530 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127.

  • Authors : Montoya S; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.; Bourcier J

Subjects: Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/genetics ; Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/metabolism ; Ikaros Transcription Factor*/Ikaros Transcription Factor*/Ikaros Transcription Factor*/metabolism

  • Source: Science (New York, N.Y.) [Science] 2024 Feb 02; Vol. 383 (6682), pp. eadi5798. Date of Electronic Publication: 2024 Feb 02.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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Academic Journal

Resisting the Resistance: Navigating BTK Mutations in Chronic Lymphocytic Leukemia (CLL).

  • Authors : Chirino A; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.; Montoya S

Subjects: Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/genetics ; Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/metabolism ; Leukemia, Lymphocytic, Chronic, B-Cell*/Leukemia, Lymphocytic, Chronic, B-Cell*/Leukemia, Lymphocytic, Chronic, B-Cell*/drug therapy

  • Source: Genes [Genes (Basel)] 2023 Dec 06; Vol. 14 (12). Date of Electronic Publication: 2023 Dec 06.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425

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Academic Journal

Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states.

  • Authors : Lin DY; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, United States.; Kueffer LE

Subjects: Agammaglobulinaemia Tyrosine Kinase*; Cryoelectron Microscopy ; Protein Domains

  • Source: ELife [Elife] 2024 Jan 08; Vol. 12. Date of Electronic Publication: 2024 Jan 08.Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet

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Academic Journal

Identification of the Axis β-Catenin-BTK in the Dynamic Adhesion of Chronic Lymphocytic Leukemia Cells to Their Microenvironment.

  • Authors : Mihoub I; INSERM, U978, 93000 Bobigny, France.; UFR SMBH, LabEx INFLAMEX, Université Paris 13-«Sorbonne Paris Nord», 93000 Bobigny, France.

Subjects: beta Catenin*/beta Catenin*/beta Catenin*/genetics ; beta Catenin*/beta Catenin*/beta Catenin*/metabolism ; Leukemia, Lymphocytic, Chronic, B-Cell*/Leukemia, Lymphocytic, Chronic, B-Cell*/Leukemia, Lymphocytic, Chronic, B-Cell*/pathology

  • Source: International journal of molecular sciences [Int J Mol Sci] 2023 Dec 18; Vol. 24 (24). Date of Electronic Publication: 2023 Dec 18.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Unlocking potential inhibitors for Bruton's tyrosine kinase through in-silico drug repurposing strategies.

  • Authors : Alrouji M; Department of Medical Laboratories, College of Applied Medical Sciences, Shaqra University, 11961, Shaqra, Saudi Arabia.; Benjamin LS

Subjects: Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/antagonists & inhibitors ; Drug Repositioning* ; Molecular Dynamics Simulation*

  • Source: Scientific reports [Sci Rep] 2023 Oct 17; Vol. 13 (1), pp. 17684. Date of Electronic Publication: 2023 Oct 17.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Influence of Bruton's Tyrosine Kinase (BTK) on Epithelial-Mesenchymal Transition (EMT) Processes and Cancer Stem Cell (CSC) Enrichment in Head and Neck Squamous Cell Carcinoma (HNSCC).

  • Authors : Leichtle F; Department of Oto-Rhino-Laryngology, Ulm University Medical Center, 89075 Ulm, Germany.; Betzler AC

Subjects: Agammaglobulinaemia Tyrosine Kinase* ; Epithelial-Mesenchymal Transition* ; Head and Neck Neoplasms*/Head and Neck Neoplasms*/Head and Neck Neoplasms*/genetics

  • Source: International journal of molecular sciences [Int J Mol Sci] 2023 Aug 23; Vol. 24 (17). Date of Electronic Publication: 2023 Aug 23.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Overexpression of Bruton Tyrosine Kinase Inhibits the Proliferation, Migration, and Invasion of Non-Small Cell Lung Cancer Cells.

  • Authors : Ren W; Department of Biotechnology, College of Life Science and Chemistry, Beijing University of Technology, Chaoyang, Beijing, China.; Yue C

Subjects: Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/genetics ; Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/genetics ; Lung Neoplasms*/Lung Neoplasms*/Lung Neoplasms*/genetics

  • Source: Analytical cellular pathology (Amsterdam) [Anal Cell Pathol (Amst)] 2023 Aug 18; Vol. 2023, pp. 3377316. Date of Electronic Publication: 2023 Aug 18 (Print Publication: Publisher: Hindawi Country of Publication: United States NLM ID: 101541993 Publication Model: eCollection Cited Medium: Internet ISSN: 2210-7185

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Academic Journal

Preclinical characterization of pirtobrutinib, a highly selective, noncovalent (reversible) BTK inhibitor.

Subjects: Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/Agammaglobulinaemia Tyrosine Kinase*/antagonists & inhibitors ; Tyrosine Kinase Inhibitors*/Tyrosine Kinase Inhibitors*/Tyrosine Kinase Inhibitors*/pharmacology ; Lymphoma*/Lymphoma*/Lymphoma*/drug therapy

  • Source: Blood [Blood] 2023 Jul 06; Vol. 142 (1), pp. 62-72.Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020

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Academic Journal

A Phase 1 First-in-Human Pharmacokinetic and Pharmacodynamic Study of JNJ-64264681, a Covalent Inhibitor of Bruton's Tyrosine Kinase.

  • Authors : Leu JH; Janssen Research & Development, LLC, Spring House, Pennsylvania, USA.; Miao X

Subjects: Agammaglobulinaemia Tyrosine Kinase* ; Tyrosine Kinase Inhibitors*/Tyrosine Kinase Inhibitors*/Tyrosine Kinase Inhibitors*/pharmacokinetics ; Tyrosine Kinase Inhibitors*/Tyrosine Kinase Inhibitors*/Tyrosine Kinase Inhibitors*/pharmacology

  • Source: Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2023 Jun; Vol. 12 (6), pp. 611-624. Date of Electronic Publication: 2023 May 01.Publisher: Wiley Country of Publication: United States NLM ID: 101572899 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  2,381 results for ""Agammaglobulinaemia Tyrosine Kinase""