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Academic Journal

Resection of DNA double-strand breaks activates Mre11-Rad50-Nbs1- and Rad9-Hus1-Rad1-dependent mechanisms that redundantly promote ATR checkpoint activation and end processing in Xenopus egg extracts.

  • Authors : Tatsukawa K; Graduate School of Systems Life Sciences, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.; Sakamoto R

Subjects: Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/genetics ; Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/metabolism ; DNA Breaks, Double-Stranded*

  • Source: Nucleic acids research [Nucleic Acids Res] 2024 Apr 12; Vol. 52 (6), pp. 3146-3163.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

DNA hypomethylation activates Cdk4/6 and Atr to induce DNA replication and cell cycle arrest to constrain liver outgrowth in zebrafish.

Subjects: Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/genetics ; Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/metabolism ; Cyclin-Dependent Kinase 4*/Cyclin-Dependent Kinase 4*/Cyclin-Dependent Kinase 4*/genetics

  • Source: Nucleic acids research [Nucleic Acids Res] 2024 Apr 12; Vol. 52 (6), pp. 3069-3087.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Therapeutic Options Targeting the Ataxia-Telangiectasia Mutated (ATM)-mediated DNA Damage Response, Macropinocytosis, and Adaptive Immunity in Ovarian Cancer.

  • Authors : Tseng CC; Department of Life Science, College of Science and Engineering, National Dong Hwa University, Hualien, Taiwan, R.O.C.; Ku MH

Subjects: Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/genetics ; Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/metabolism ; Ovarian Neoplasms*/Ovarian Neoplasms*/Ovarian Neoplasms*/drug therapy

  • Source: Anticancer research [Anticancer Res] 2024 Apr; Vol. 44 (4), pp. 1353-1364.Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8102988 Publication Model: Print Cited Medium: Internet

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Academic Journal

ATR blocks telomerase from converting DNA breaks into telomeres.

  • Authors : Kinzig CG; Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10065, USA.; Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD/PhD Program, New York, NY 10065, USA.

Subjects: Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/genetics ; Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/metabolism ; DNA Breaks, Double-Stranded*

  • Source: Science (New York, N.Y.) [Science] 2024 Feb 16; Vol. 383 (6684), pp. 763-770. Date of Electronic Publication: 2024 Feb 15.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic

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Academic Journal

Germline testing of BRCA1 , BRCA2 , PALB2 and CHEK2 c.1100delC in 1514 triple negative familial and isolated breast cancers from a single centre, with extended testing of ATM , RAD51C and RAD51D in over 400.

  • Authors : Woodward ER; Manchester Centre for Genomic Medicine, Manchester University Hospitals NHS Foundation Trust, Manchester, UK.; Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

Subjects: Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/genetics ; Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/genetics ; Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/Triple Negative Breast Neoplasms*/pathology

  • Source: Journal of medical genetics [J Med Genet] 2024 Mar 21; Vol. 61 (4), pp. 385-391. Date of Electronic Publication: 2024 Mar 21.Publisher: British Medical Association Country of Publication: England NLM ID: 2985087R Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

ATM-Mediated translocation of RanBPM regulates DNA damage response by stabilizing p21 in non-small cell lung cancer cells.

  • Authors : Deng T; Center for Clinical Precision Pharmacy, The First Affiliated Hospital, Guangdong Pharmaceutical University, 19 Nonglinxia Road, Yuexiu District, Guangzhou, Guangdong, China. .; Clinical Pharmacy, The First Affiliated Hospital, Guangdong Pharmaceutical University, Guangzhou, China. .

Subjects: Adaptor Proteins, Signal Transducing* ; Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/metabolism ; Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/genetics

  • Source: Cellular oncology (Dordrecht) [Cell Oncol (Dordr)] 2024 Feb; Vol. 47 (1), pp. 245-258. Date of Electronic Publication: 2023 Sep 07.Publisher: Springer Country of Publication: Netherlands NLM ID: 101552938 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The ATM Ser49Cys Variant Effects ATM Function as a Regulator of Oncogene-Induced Senescence.

Subjects: Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/genetics ; Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/metabolism ; Melanoma*/Melanoma*/Melanoma*/geneticsAtaxia-Telangiectasia Variant

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 29; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 29.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

ATM, KAP1 and the Epstein-Barr virus polymerase processivity factor direct traffic at the intersection of transcription and replication.

  • Authors : Xu H; Division of Infectious Diseases, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.; Akinyemi IA

Subjects: Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/genetics ; Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/metabolism ; Epstein-Barr Virus Infections*

  • Source: Nucleic acids research [Nucleic Acids Res] 2023 Nov 10; Vol. 51 (20), pp. 11104-11122.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Ethnicity-specific BRCA1, BRCA2, PALB2, and ATM pathogenic alleles in breast and ovarian cancer patients from the North Caucasus.

  • Authors : Sokolenko AP; Department of Tumor Growth Biology, N.N. Petrov Institute of Oncology, Leningradskaya, 68, Pesochny-2, St. Petersburg, Russia, 197758. .; St. Petersburg Pediatric Medical University, St. Petersburg, Russia. .

Subjects: Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/genetics ; Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/pathology ; Ovarian Neoplasms*/Ovarian Neoplasms*/Ovarian Neoplasms*/genetics

  • Source: Breast cancer research and treatment [Breast Cancer Res Treat] 2024 Jan; Vol. 203 (2), pp. 307-315. Date of Electronic Publication: 2023 Oct 18.Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 8111104 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

The epigenetic modifier HDAC2 and the checkpoint kinase ATM determine the responses of microsatellite instable colorectal cancer cells to 5-fluorouracil.

  • Authors : Kiweler N; Department of Toxicology, University Medical Center Mainz, 55131, Mainz, Germany.; Department of Cancer Research, Luxembourg Institute of Health, L-1526, Luxembourg, Luxembourg.

Subjects: Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/genetics ; Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/metabolism ; Colonic Neoplasms*

  • Source: Cell biology and toxicology [Cell Biol Toxicol] 2023 Oct; Vol. 39 (5), pp. 2401-2419. Date of Electronic Publication: 2022 May 24.Publisher: Springer Country of Publication: Switzerland NLM ID: 8506639 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  7,333 results for ""Ataxia Telangiectasia Mutated Proteins""