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Elotuzumab Enhances CD16-Independent NK Cell-Mediated Cytotoxicity against Myeloma Cells by Upregulating Several NK Cell-Enhancing Genes.

• Authors : Wang, Yan-Hua¹ (AUTHOR); Hagiwara, Shotaro¹ (AUTHOR); Kazama, Hiroshi^1,2 (AUTHOR)

Subjects: *CELL-mediated cytotoxicity; *ANTIBODY-dependent cell cytotoxicity; *MONONUCLEAR leukocytes

• Source: Journal of Immunology Research. 2/27/2024, Vol. 2024, p1-18. 18p.

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Agricola

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Findings on Breast Cancer Reported by Investigators at Cornell University (Collagen Mineralization Decreases Nk Cell-mediated Cytotoxicity of Breast Cancer Cells Via Increased Glycocalyx Thickness)

• Source: Women's Health Weekly. March 7, 2024, 2441

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Agricola

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Anti-PD-L1 antibody enhances curative effect of cryoablation via antibody-dependent cell-mediated cytotoxicity mediating PD-L1highCD11b+ cells elimination in hepatocellular carcinoma.

• Authors : Tan, Jizhou; Liu, Ting; Fan, Wenzhe

Subjects: ANTIBODY-dependent cell cytotoxicity; KILLER cells; HEPATOCELLULAR carcinoma

• Source: Acta Pharmaceutica Sinica B; Feb2023, Vol. 13 Issue 2, p632-647, 16p

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Granzyme F: Exhaustion Marker and Modulator of Chimeric Antigen Receptor T Cell-Mediated Cytotoxicity.

• Authors : Hay ZLZ; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO.; Kim DD

Subjects: Leukemia*/Leukemia*/Leukemia*/metabolism ; Receptors, Chimeric Antigen*/Receptors, Chimeric Antigen*/Receptors, Chimeric Antigen*/metabolism; Animals

• Source: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2024 Apr 15; Vol. 212 (8), pp. 1381-1391.Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print Cited Medium: Internet

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Cholesterol-regulated cellular stiffness may enhance evasion of NK cell-mediated cytotoxicity in gastric cancer stem cells.

• Authors : Zhu L; Department of Radiation Oncology (II), The First Affiliated Hospital of Jinzhou Medical University, China.; Wang H

• Source: FEBS open bio [FEBS Open Bio] 2024 Mar 17. Date of Electronic Publication: 2024 Mar 17.Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 101580716 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Cytotoxic activity and gene expression during in vitro adaptive cell-mediated cytotoxicity of head-kidney cells from betanodavirus-infected European sea bass.

• Authors : García-Álvarez MA; Immunobiology for Aquaculture Group, Department of Cell Biology and Histology, Faculty of Biology, University of Murcia, 30100, Murcia, Spain.; Chaves-Pozo E

Subjects: Bass* ; Nodaviridae*/Nodaviridae*/Nodaviridae*/physiology ; Antineoplastic Agents*

• Source: Developmental and comparative immunology [Dev Comp Immunol] 2024 Mar; Vol. 152, pp. 105124. Date of Electronic Publication: 2023 Dec 23.Publisher: Elsevier Science Country of Publication: United States NLM ID: 7708205 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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A CRISPR activation screen identifies MUC-21 as critical for resistance to NK and T cell-mediated cytotoxicity

• Authors : Lee, Dong-hee; Ahn, Hyejin; Sim, Hye-In

• Source: Journal of Experimental & Clinical Cancer Research. October 20, 2023, Vol. 42 Issue 1

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NK cell–mediated cytotoxicity contributes to tumor control by a cytostatic drug combination.

• Authors : Ruscetti, Marcus; Leibold, Josef; Bott, Matthew J.

Subjects: KILLER cells; CELL-mediated cytotoxicity; TUMOR treatment

• Source: Science. 12/21/2018, Vol. 362 Issue 6421, p1416-1422. 7p. 4 Color Photographs.

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NKG2D promotes CD8 T cell-mediated cytotoxicity and is associated with treatment failure in human cutaneous leishmaniasis

• Authors : Sacramento, Laís A.; Farias Amorim, Camila; Campos, Taís M.

• Source: PLoS Neglected Tropical Diseases. August 21, 2023, Vol. 17 Issue 8, pe0011552.

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Research on Ovarian Cancer Discussed by Researchers at Shanghai Jiao Tong University School of Medicine (ANGPTL3 affects the metastatic potential and the susceptibility of ovarian cancer cells to natural killer cell-mediated cytotoxicity)

• Source: Women's Health Weekly. August 31, 2023, p5522.

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gd T cell-mediated cytotoxicity against patient-derived healthy and cancer cervical organoids

• Source: Women's Health Weekly. August 10, 2023, p7106.

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U.S. Patent and Trademark Office Publishes IO Biotech APS's Patent Application for Enhancement of Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC).

• Source: Global IP News: Chemical Patent News. 2024.

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THE CYTOTOXIC EFFECT OF SOME SYNTHETIC NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS ON CULTURES OF TUMOUR AND NORMAL CELLS AND THE CALCULATION OF THEIR ADME, QSAR, AND DFT PHARMACOLOGICAL PROPERTIES.

• Authors : Vdovin, Vasyl¹ ; Yarmoluk, Sergiy²

Subjects: *HETEROCYCLIC compounds; *CELL-mediated cytotoxicity; *IMIDAZOLES

• Source: ScienceRise: Biological Science. 2022, Vol. 30 Issue 1, p61-69. 4p.

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Antibody dependent cell-mediated cytotoxicity selection pressure induces diverse mechanisms of resistance.

• Authors : Zahavi DJ; Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, USA.; Erbe R

Subjects: Proteomics* ; Antibody-Dependent Cell Cytotoxicity*; Humans

• Source: Cancer biology & therapy [Cancer Biol Ther] 2023 Dec 31; Vol. 24 (1), pp. 2269637. Date of Electronic Publication: 2023 Oct 25.Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101137842 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Education Full Text (H.W. Wilson)

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Collagen Mineralization Decreases NK Cell-Mediated Cytotoxicity of Breast Cancer Cells via Increased Glycocalyx Thickness.

• Authors : Park S; Graduate Field of Biophysics, Cornell University, Ithaca, NY, 14853, USA.; Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, 14853, USA.

• Source: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2024 Jan 27, pp. e2311505. Date of Electronic Publication: 2024 Jan 27.Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9885358 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4095

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Department of Hematology Researcher Highlights Recent Research in Myeloma (Elotuzumab Enhances CD16-Independent NK Cell-Mediated Cytotoxicity against Myeloma Cells by Upregulating Several NK Cell-Enhancing Genes)

• Source: Immunotherapy Weekly. March 20, 2024, 1180

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Effects of sevoflurane on metalloproteinase and natural killer group 2, member D (NKG2D) ligand expression and natural killer cell-mediated cytotoxicity in breast cancer: an in vitro study.

• Authors : Kim HJ; Department of Anesthesia and Pain Medicine, Pusan National University School of Medicine, Busan, Korea.; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.

Subjects: Breast Neoplasms* ; Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/metabolism ; Liver Neoplasms*/Liver Neoplasms*/Liver Neoplasms*/metabolism

• Source: Korean journal of anesthesiology [Korean J Anesthesiol] 2023 Dec; Vol. 76 (6), pp. 627-639. Date of Electronic Publication: 2023 Aug 21.Publisher: Korean Society of Anesthesiologists Country of Publication: Korea (South) NLM ID: 101502451 Publication Model: Print-Electronic Cited Medium:

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γδ T cell-mediated cytotoxicity against patient-derived healthy and cancer cervical organoids.

• Authors : Dong J; Laboratory of Infection Oncology, Institute of Clinical Molecular Biology, Christian-Albrechts-Universität zu Kiel and University Hospital Schleswig-Holstein, Kiel, Germany.; Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany.

Subjects: Uterine Cervical Neoplasms*; Humans ; Female

• Source: Frontiers in immunology [Front Immunol] 2023 Nov 27; Vol. 14, pp. 1281646. Date of Electronic Publication: 2023 Nov 27 (Print Publication: 2023).Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet

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XPO1 inhibition sensitises CLL cells to NK cell mediated cytotoxicity and overcomes HLA-E expression.

• Authors : Fisher JG; School of Clinical and Experimental Sciences, University of Southampton, Southampton, UK.; Doyle ADP

Subjects: Karyopherins*/Karyopherins*/Karyopherins*/antagonists & inhibitors ; Karyopherins*/Karyopherins*/Karyopherins*/metabolism ; Leukemia, Lymphocytic, Chronic, B-Cell*/Leukemia, Lymphocytic, Chronic, B-Cell*/Leukemia, Lymphocytic, Chronic, B-Cell*/drug therapy

• Source: Leukemia [Leukemia] 2023 Oct; Vol. 37 (10), pp. 2036-2049. Date of Electronic Publication: 2023 Aug 01.Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium:

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Longitudinal transcriptional changes reveal genes from the natural killer cell-mediated cytotoxicity pathway as critical players underlying COVID-19 progression.

• Source: Medical Letter on the CDC & FDA. 2024, pages. 50

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Cerebrospinal fluid cytotoxicity does not affect survival in amyotrophic lateral sclerosis.

• Authors : Galán, L.; Matías‐Guiu, J.; Matias‐Guiu, J. A.

Subjects: AMYOTROPHIC lateral sclerosis; CELL-mediated cytotoxicity; CEREBROSPINAL fluid

• Source: Acta Neurologica Scandinavica. Sep2017, Vol. 136 Issue 3, p212-216. 5p.

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Agricola

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